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公开(公告)号：EP1919920A2
公开(公告)日：2008-05-14
申请号：EP06813425.3
申请日：2006-08-14
发明人： RAWSON, Thomas, E. , SAFINA, Brian , DOTSON, Jennafer , ALIAGAS-MARTIN, Ignacio , HALLADAY, Jason , LIANG, Jun , RUETH, Matthias , ZHU, Bing-Yan , BROOKFIELD, Frederick , PRIME, Michael , ZHANG, Birong , LI, Jun, M. , Zhou, Aihe.
IPC分类号： C07D487/04 , C07D491/04 , A61K31/4155 , A61P35/00
CPC分类号： C07D487/04 , C07D491/04
摘要： The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula: (I) wherein A, X, Y, Z, Ra, Rb, Rc, R1 , R2, R3 and m are defined herein.
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公开(公告)号：EP2547338A2
公开(公告)日：2013-01-23
申请号：EP11708831.0
申请日：2011-03-15
发明人： LAI, Yingjie , LIANG, Jun , MAGNUSON, Steven R. , TSUI, Vickie H. , ZHANG, Birong , ROBARGE, Kirk
IPC分类号： A61K31/437 , A61K31/4406 , A61K31/4409 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/541 , C07D471/04 , C07D473/34 , C07D491/107 , A61P1/00 , A61P17/06 , A61P29/00
CPC分类号： C07D471/04 , C07D473/00 , C07D473/34 , C07D519/00
摘要： The invention provides compounds of Formulas Ia-Ib, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R
1 , R
2 , R
4 , R
5 and R
16 are defined herein, a pharmaceutical composition that includes a compound of Formulas Ia-Ib and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of using the compound or composition in therapy.-
公开(公告)号：EP2640722B1
公开(公告)日：2015-11-04
申请号：EP11790910.1
申请日：2011-11-17
发明人： BLENCH, Toby , GOODACRE, Simon , LAI, Yingjie , LIANG, Jun , MACLEOD, Calum , MAGNUSON, Steven , TSUI, Vickie , WILLIAMS, Karen , ZHANG, Birong
IPC分类号： C07D471/04 , C07D487/04 , A61K31/37 , A61K31/519 , A61P11/02 , A61P11/06 , A61P17/06 , A61P19/02
CPC分类号： C07D471/04 , C07D487/04
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公开(公告)号：EP2758397A1
公开(公告)日：2014-07-30
申请号：EP12766626.1
申请日：2012-09-19
发明人： LAI, Yingjie , LIANG, Jun , MAGNUSON, Steven, R. , ROBARGE, Kirk, D. , TSUI, Vickie, Hsaio-Wei , ZHANG, Birong
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04
摘要： The invention provides TYK2 inhibitors of Formulas (la-lb), stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R
a , R
1 , R
2 , R
4 , R
5 and R
16 are defined herein, a pharmaceutical composition that includes a compound of Formulas (la-lb) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of using the compound or composition in the therapy of inflammatory diseases.-
5.发明公开
公开(公告)号：EP2616072A1
公开(公告)日：2013-07-24
申请号：EP11757296.6
申请日：2011-09-14
发明人： BLENCH, Toby , ELLWOOD, Charles , GOODACRE, Simon , LAI, Yingjie , LIANG, Jun , MACLEOD, Calum , MAGNUSON, Steven , TSUI, Vickie , WILLIAMS, Karen , ZHANG, Birong
IPC分类号： A61K31/429 , C07D513/00 , A61P29/00
CPC分类号： A61K31/5377 , A61K31/437 , A61K31/501 , A61K31/506 , A61K31/519 , C07D513/04
摘要： Provided are compounds of Formula I, stereoisomers, tautomers, solvates, prodrugs and pharmaceutically acceptable salts thereof, wherein A, X, R
1 , R
2 , R
4 and R
5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, and methods of 5 manufacturing a compound of Formula I.摘要翻译： 提供了式I化合物，其立体异构体，互变异构体，溶剂化物，前药和药学上可接受的盐，其中A，X，R 1，R 2，R 4和R 5如本文所定义，药物组合物包含式I 和药学上可接受的载体，佐剂或赋形剂，在治疗中使用所述化合物或组合物的方法，以及制备式I化合物的方法。
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6.发明公开PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDINES AND THEIR USE AS TYK2 INHIBITORS 有权PYRAZOLPYRIDINE及其作为抑制剂TYK2
公开(公告)号：EP2640722A1
公开(公告)日：2013-09-25
申请号：EP11790910.1
申请日：2011-11-17
发明人： BLENCH, Toby , GOODACRE, Simon , LAI, Yingjie , LIANG, Jun , MACLEOD, Calum , MAGNUSON, Steven , TSUI, Vickie , WILLIAMS, Karen , ZHANG, Birong
IPC分类号： C07D471/04 , C07D487/04 , A61K31/37 , A61K31/519 , A61P11/02 , A61P11/06 , A61P17/06 , A61P19/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention provides compounds of Formula (I), stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R
1 , R
2 , R
4 and R
5 are defined herein, a pharmaceutical composition that includes a compound of Formula (I) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of using the compound or composition in therapy, as TYK2 Kinase inhibitors.-
公开(公告)号：EP2440529A1
公开(公告)日：2012-04-18
申请号：EP10721178.1
申请日：2010-06-10
发明人： GOODACRE, Simon Charles , LAI, Yingjie , LIANG, Jun , MAGNUSON, Steven R. , ROBARGE, Kirk D. , STANLEY, Mark S. , TSUI, Vickie Hsiao-Wei , WILLIAMS, Karen , ZHANG, Birong , ZHOU, Aihe
IPC分类号： C07D213/75 , C07D401/12 , A61K31/506 , A61K31/495 , A61K31/4439 , A61K31/444 , A61P37/04
CPC分类号： C07D213/75 , C07D401/12
摘要： The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, B, D, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and methods of use thereof.
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公开(公告)号：EP1919920B1
公开(公告)日：2011-05-18
申请号：EP06813425.3
申请日：2006-08-14
发明人： RAWSON, Thomas, E. , SAFINA, Brian , DOTSON, Jennafer , ALIAGAS-MARTIN, Ignacio , HALLADAY, Jason , LIANG, Jun , RUETH, Matthias , ZHU, Bing-Yan , BROOKFIELD, Frederick , PRIME, Michael , ZHANG, Birong , LI, Jun, M. , Zhou, Aihe
IPC分类号： C07D487/04 , C07D491/04 , A61K31/4155 , A61P35/00
CPC分类号： C07D487/04 , C07D491/04
摘要： The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula: (I) wherein A, X, Y, Z, Ra, Rb, Rc, R1 , R2, R3 and m are defined herein.
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