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1.发明公开PROPANE- I-SULFONIC ACID {3- [5- (4 -CHLORO-PHENYL) -1H-PYRROLO [2, 3-B] PYRIDINE-3-CARBONYL] -2, 4-DIFLUORO-PHENY L } -AMIDE COMPOSITIONS AND USES THEREOF 有权丙烷-1-磺酸{3- [5-（4-氯苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟苯基}酰胺的组合物及其应用
公开(公告)号：EP2414356A2
公开(公告)日：2012-02-08
申请号：EP10722860.3
申请日：2010-03-31
发明人： DESAI, Dipen , DIODONE, Ralph , GO, Zenaida , IBRAHIM, Prabha, N. , IYER, Raman, Mahadevan , MAIR, Hans-Juergen , SANDHU, Harpreet, K. , SHAH, Navnit, Hargovindas , VISOR, Gary, Conard , WYTTENBACH, Nicole , LAUPER, Stephan , PUDEWELL, Johannes , WIERSCHEM, Frank
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
摘要： Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1 -sulfonic acid {3-[5-(4-chloro-pheny!)-lH-pyrrolo[2,3-b]pyridine-3-carbonyl]- 2,4-difluoro-phenyl} -amide. (Formula I).
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2.发明授权PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF 有权丙烷-1-磺酸{3- [5-（4-氯苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟苯基}酰胺的组合物及其应用
公开(公告)号：EP2414356B1
公开(公告)日：2015-09-02
申请号：EP10722860.3
申请日：2010-03-31
发明人： DESAI, Dipen , DIODONE, Ralph , GO, Zenaida , IBRAHIM, Prabha, N. , IYER, Raman, Mahadevan , MAIR, Hans-Juergen , SANDHU, Harpreet, K. , SHAH, Navnit, Hargovindas , VISOR, Gary, Conard , WYTTENBACH, Nicole , LAUPER, Stephan , PUDEWELL, Johannes , WIERSCHEM, Frank
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
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3.发明公开PROPANE-I-SULFONIC ACID {3- [5- (4- CHLORO-PHENYL) -1H-PYRROLO [2, 3-B} PYRIDINE-3-CARBONYL] -2, 4-DIFLUORO-PHENYL} -AMIDE COMPOSITIONS AND USES THEREOF 有权丙烷-1-磺酸{3- [5-（4-氯 - 苯基）-1H-吡咯并[2,3-B]吡啶-3-羰基] -2,4-二氟 - 苯基} - 酰胺组合物和用途 THEREOF
公开(公告)号：EP2955180A1
公开(公告)日：2015-12-16
申请号：EP15171526.5
申请日：2010-03-31
发明人： DESAI, Dipen , DIODONE, Ralph , GO, Zenaida , IBRAHIM, Prabha N. , IYER, Raman Mahadevan , MAIR, Hans-Juergen , SANDHU, Harpreet, K. , SHAH, Navnit Hargovindas , VISOR, Gary Conard , WYTTENBACH, Nicole , LAUPER, Stephan , PUDEWELL, Johannes , WIERSCHEM, Frank
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
摘要： Provided are crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
摘要翻译： 提供了涉及丙烷-1-磺酸{3- [5-（4-氯 - 苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟 - 苯基} - 酰胺。
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4.发明公开PROPANE-I-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE COMPOSITIONS AND USES THEREOF 审中-公开丙-1-硫酸{3- [5-（4-氯 - 苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基] -2,4-二氟 - 苯基} - 酰胺和组合物 用途
公开(公告)号：EP2499138A1
公开(公告)日：2012-09-19
申请号：EP10775810.4
申请日：2010-11-08
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K31/437 , C07B2200/13
摘要： The present invention is related to an improved method for the manufacture of Micro- precipitated Bulk Powder (MBP) containing the active pharmaceutical ingredient Propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS). The invention is further directed to pharmaceutical compositions containing said MBP, as well as its use in the manufacture of medicaments for the treatment of cancer. Formula (I).
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