公开(公告)号：EP3005199A4

公开(公告)日：2017-05-10

申请号：EP14804788

申请日：2014-05-28

申请人： FIVE3 GENOMICS LLC

发明人： BENZ STEPHEN CHARLES ,  SZETO CHRISTOPHER

IPC分类号： G06F19/12

CPC分类号： G06F19/10 ,  G06F19/12 ,  G06F19/345 ,  G16H50/20

摘要： Systems and methods are presented in which omics data from multiple cell or tissue samples are used to identify pathway elements that are associated with a treatment parameter of the cell or tissue (e.g., resistance towards a specific drug). So identified pathway elements are then modulated in silico in a statistical factor graph model to provide a modified data set that is re-evaluated with respect to the treatment parameter. Such systems and models are particularly useful for recommendation of multi-drug treatments for treatment-nave patients.

摘要翻译： 呈现了系统和方法，其中使用来自多个细胞或组织样品的组学数据来识别与细胞或组织的治疗参数（例如对特定药物的抗性）相关的通路元件。 如此识别的通路元件然后在统计因子图模型中以计算机模块（in silico）被调制，以提供经修改的数据集，其相对于治疗参数被重新评估。 这样的系统和模型对推荐治疗中心患者的多药物治疗特别有用。