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23 条记录 (耗时 0.011 秒)

    PARADIGM DRUG RESPONSE NETWORKS
    2.
    发明公开
    PARADIGM DRUG RESPONSE NETWORKS 有权
    范式药ADDRESS网络

    公开(公告)号：EP3005199A1

    公开(公告)日：2016-04-13

    申请号：EP14804788.9

    申请日：2014-05-28

    申请人： Five3 Genomics, LLC

    发明人： BENZ, Stephen Charles ,  SZETO, Christopher

    IPC分类号： G06F19/10

    CPC分类号： G16B99/00 ,  G16B5/00 ,  G16H50/20

    摘要： Systems and methods are presented in which omics data from multiple cell or tissue samples are used to identify pathway elements that are associated with a treatment parameter of the cell or tissue (e.g., resistance towards a specific drug). So identified pathway elements are then modulated in silico in a statistical factor graph model to provide a modified data set that is re-evaluated with respect to the treatment parameter. Such systems and models are particularly useful for recommendation of multi-drug treatments for treatment-nave patients.

    SYSTEMS AND METHODS FOR RNA ANALYSIS IN FUNCTIONAL CONFIRMATION OF CANCER MUTATIONS
    6.
    发明公开
    SYSTEMS AND METHODS FOR RNA ANALYSIS IN FUNCTIONAL CONFIRMATION OF CANCER MUTATIONS 审中-公开
    系统和方法用于RNA分析在癌症突变的功能确认书

    公开(公告)号：EP3129908A1

    公开(公告)日：2017-02-15

    申请号：EP15768442.4

    申请日：2015-03-25

    申请人： Five3 Genomics, LLC

    发明人： SANBORN, John Zachary

    IPC分类号： G06F19/18 ,  G06F19/28

    CPC分类号： G06F19/18 ,  G06F19/22 ,  G06F19/28

    摘要： Contemplated systems and methods integrate genomic/exomic data with transcriptomic data by correlating a cancer associated mutation in the genome/exome with the transcription level of the affected gene carrying the mutation, particularly where the mutation is a 3-terminal nonsense mutation.

    摘要翻译： 考虑的系统和方法通过关联在基因组/外显子组与癌症相关的突变与受影响的基因携带突变，特别是其中所述突变是3端子无义突变的转录水平与整合转录数据的基因组/ exomic数据。

    SYSTEMS AND METHODS FOR TUMOR CLONALITY ANALYSIS
    7.
    发明公开
    SYSTEMS AND METHODS FOR TUMOR CLONALITY ANALYSIS 审中-公开
    用于肿瘤克隆分析的系统和方法

    公开(公告)号：EP2907062A1

    公开(公告)日：2015-08-19

    申请号：EP13845204.0

    申请日：2013-11-07

    申请人： Five3 Genomics, LLC

    发明人： SANBORN, John Zachary

    IPC分类号： G06F19/10

    摘要： Systems and methods of genomic analysis are presented that provide a framework to determine a tumor's clonality, the number and proportion of all major clones, and the variants that distinguish them. Contemplated systems and methods also allow phasing mutations to parental alleles to so time their emergence within the population of tumor cells, and provide an accurate estimate of the amount of contaminating normal tissue that was present in the tumor biopsy.

    摘要翻译： 提供了基因组分析的系统和方法，其提供了确定肿瘤克隆性的框架，所有主要克隆的数量和比例以及区分它们的变体。 考虑到的系统和方法还允许对亲本等位基因进行定相突变以使其出现在肿瘤细胞群中，并且提供对存在于肿瘤活检中的污染正常组织的量的准确估计。