公开(公告)号：EP4092107A1

公开(公告)日：2022-11-23

申请号：EP21741077.8

申请日：2021-01-15

申请人： FUJIFILM Corporation

发明人： MURAKAMI Yuta ,  NAGASE Masaya ,  MAEDA Kiyohiro ,  SHIRAISHI Yasushi ,  KOCHI Masahiro

IPC分类号： C12N5/071 ,  C12N5/0735 ,  C12N5/077 ,  C12N5/10 ,  C12Q1/06

摘要： An object of the present invention is to provide a method of producing a pluripotent stem cell capable of differentiating into a specific cell. According to the present invention, there is provided a method for producing a pluripotent stem cell capable of differentiating into a specific cell, the method including (i) a step of measuring, in a pluripotent stem cell as a sample, a phenotype associated with induction of epithelial-mesenchymal transition before differentiation induction; and (ii) a step of acquiring a pluripotent stem cell capable of differentiating into a specific cell using the measured phenotype as an indicator. According to the present invention, there are further provided a method of selecting a pluripotent stem cell capable of differentiating into a specific cell; a pluripotent stem cell capable of differentiating into a specific cell; a production method of a differentiated cell; a differentiated cell; and a method for quality evaluation of a pluripotent stem cell.