公开(公告)号：EP0781997A1

公开(公告)日：1997-07-02

申请号：EP96402913.6

申请日：1996-12-27

申请人： FUJIREBIO Inc. ,  AUBEX CORPORATION

发明人： Kakutani, Masami ,  Sakuda, Ryutaro ,  Yanagiya, Takayuki ,  Kanai, Masahiro

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/545 ,  G01N33/553

CPC分类号： G01N33/5302 ,  G01N33/54366

摘要： An instrument for simplified immunoassay (1) for detecting the presence of at least one of an antigen or an antibody in a liquid specimen, includes a rod-shaped core member (2) which bears thereon at least one labeled antigen or antibody zone (X) including a labeled antigen or a labeled antibody, the labeled antigen and the labeled antibody respectively being capable of reacting with the antibody and the antigen in the liquid specimen, each forming a labeled antigen-antibody complex, and a detection zone (Y) disposed above the labeled antigen or antibody zone (X), the detection zone (Y) including an antigen or an antibody capable of reacting with the labeled antigen-antibody complex, and a cover member (3) which covers the outer peripheral surface of the rod-shaped core member (2), through which the labeled antigen or antibody zone (X) and the detection zone (Y) formed on the outer peripheral surface of the rod-shaped core member (2) are visible, with a capillary portion being provided between the rod-shaped core member (2) and the cover member (3), through which capillary portion the liquid specimen is carried upward from a base portion thereof so as to have the liquid specimen reach the labeled antigen or antibody zone (X) and then the detection zone (Y). A simplified immunoassay method using this instrument is provided.

摘要翻译： 用于检测液体样品中至少一种抗原或抗体存在的简化免疫测定（1）的仪器包括：杆状核心部件（2），其承载至少一个标记的抗原或抗体区域（X ）包括标记的抗原或标记的抗体，标记的抗原和标记的抗体分别能够与液体样品中的抗体和抗原反应，每个形成标记的抗原 - 抗体复合物和设置的检测区（Y） 在标记的抗原或抗体区（X）上方的检测区（Y），包含能够与标记的抗原 - 抗体复合物反应的抗原或抗体的检测区（Y）和覆盖杆的外周面的覆盖部件 （2）上形成的标记的抗原或抗体区域（X）和检测区域（Y）可见，其中毛细管部分为 提供 在杆状芯体（2）和盖部件（3）之间，使毛细管部分从液体样本的基部向上方携带，以使液体样本达到标记的抗原或抗体区域（X） 然后检测区（Y）。 提供使用该仪器的简化免疫测定方法。

公开(公告)号：EP0274264A1

公开(公告)日：1988-07-13

申请号：EP87311262.7

申请日：1987-12-21

申请人： FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.

发明人： Uchida, Yoshiaki ,  Honda, Hideo ,  Kikuchi, Yousuke ,  Kakutani, Masami

IPC分类号： G01N33/577 ,  G01N33/574 ,  G01N33/543 ,  G01N33/555 ,  C12P21/00

CPC分类号： G01N33/555 ,  C07K16/30 ,  C07K16/3046

摘要： A reagent for detecting CA19-9 antigen by reverse particle agglutination comprises, sensitised on carrier particles, a novel IgM class monoclonal antibody which recognises an antigenic determinant of CA19-9. The reagent is useful for the diagnosis of digestive organ cancers, particularly pancreas cancer.

摘要翻译： 用于通过反向颗粒凝集检测CA19-9抗原的试剂包括在载体颗粒上敏化的识别CA19-9的抗原决定簇的新型IgM类单克隆抗体。 该试剂可用于诊断消化器官癌，特别是胰腺癌。