公开(公告)号：EP0995742A4

公开(公告)日：2004-08-25

申请号：EP98929715

申请日：1998-06-24

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： KAYAKIRI HIROSHI ,  ABE YOSHITO ,  HAMASHIMA HITOSHI ,  SAWADA HITOSHI ,  MIZUTANI TSUYOSHI ,  YAMASAKI NORITSUGU ,  ONOMURA OSAMU ,  NISHIKAWA MASAHIRO ,  HIRAMURA TAKAHIRO ,  OKU TERUO ,  IMOTO TAKAFUMI

IPC分类号： G06Q50/10 ,  A61K20060101 ,  A61K31/381 ,  A63B69/36 ,  C07D20060101 ,  C07D215/48 ,  C07D231/56 ,  C07D239/96 ,  C07D241/52 ,  C07D249/18 ,  C07D307/79 ,  C07D333/54 ,  C07D333/56 ,  C07D333/62 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F20060101 ,  A61K31/34 ,  A61K31/38 ,  A61K31/415 ,  A61K31/437 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  C07D235/26

CPC分类号： C07D241/52 ,  C07D215/48 ,  C07D231/56 ,  C07D239/96 ,  C07D249/18 ,  C07D307/79 ,  C07D333/54 ,  C07D333/62 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： Sulfonamide compounds represented by the general formula (I) R1-SO2NHCO-A-X-R2, salts thereof, and medicinal compositions containing the same. In said formula, R1 represents alkyl, alkenyl, alkynyl, etc.; A represents an optionally substituted polyheterocyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenz-imidazolyl and 2,3-dihydrobenzoxazinyl; X represents alkylene, oxygen, oxygenated lower alkylene, etc.; and R2 represents optionally substituted aryl, substituted biphenylyl, etc. These compounds are useful in treating diseases curable based on the hypoglycemic effect, and diseases curable based on the cGMP-PDE inhibitory, leiolytic, bronchodilating, vasodilating, smooth muscle cell inhibitory, and antiallergic effects.