公开(公告)号：EP1070705A4

公开(公告)日：2002-04-17

申请号：EP99912110

申请日：1999-04-05

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： YAMASAKI NORITSUGU ,  IMOTO TAKAFUMI ,  OKU TERUO ,  KAYAKIRI HIROSHI ,  ONOMURA OSAMU ,  HIRAMURA TAKAHIRO

IPC分类号： C07D209/10 ,  C07D209/12 ,  C07D405/10 ,  C07D409/10 ,  C07D409/12 ,  A61K31/404

CPC分类号： C07D405/10 ,  C07D209/10 ,  C07D209/12 ,  C07D409/10 ,  C07D409/12

摘要： Novel indole derivatives represented by formula (I) or salts thereof, wherein R1 is aryl-substituted lower alkyl in which the aryl may be substituted by at least one member selected among halogen atoms, aryls, heterocyclic groups, aryl-substituted lower alkyls, aryl-substituted lower alkenyls, lower haloalkyls, (lower cycloalkyl)-substituted lower alkyloxys, (lower cycloalkyloxy)-substituted lower alkyls, aryl-substituted lower alkynyls, aryloxy-substituted lower alkyls, aryl-substituted lower alkyloxys, lower alkylthios, lower alkyloxys, and alkenyls; and R2 is a lower alkyl, lower alkenyl, aryl, or heterocyclic group optionally substituted by halogeno, lower alkyl, lower alkenyl, or aryl. These compounds have a hypoglycemic activity and a PDE5 inhibitory activity and are useful as a drug.

公开(公告)号：EP1000932A4

公开(公告)日：2000-08-09

申请号：EP98929724

申请日：1998-06-26

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： YAMASAKI NORITSUGU ,  IMOTO TAKAFUMI ,  HIRAMURA TAKAHIRO ,  ONOMURA OSAMU ,  NISHIKAWA MASAHIRO ,  KAYAKIRI HIROSHI ,  ABE YOSHITO ,  HAMASHIMA HITOSHI ,  SAWADA HITOSHI

IPC分类号： C07C311/51 ,  C07D213/78 ,  C07D213/81 ,  C07D233/54 ,  C07D233/56 ,  C07D233/64 ,  C07D233/68 ,  C07D409/06 ,  A61K31/18 ,  A61K31/415 ,  A61K31/44 ,  C07D213/56 ,  C07D409/12

CPC分类号： C07D213/78 ,  C07C311/51 ,  C07D213/81 ,  C07D233/64 ,  C07D233/68 ,  C07D409/06

摘要： Novel aromatic ring derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof. Because of having hypoglycemic and PDE 5 inhibitory activities, these compounds and salts thereof are useful as remedies for impaired glucose tolerance, diabetes, complication of diabetes, insulin-resistant syndrome, polycystic ovary syndrome, hyperlipidemia, atherosclerosis, cardio-vascular diseases, hyperglycemia, hypertension, angina pectoris, pulmonary hypertension, congestive heart failure, glomerular diseases, tubular interstitial diseases, renal insufficiency, atherosclerosis, angiostenosis, peripheral vascular diseases, cerebral stroke, chronic reversible obstructive diseases, autoimmune diseases, allergic rhinitis, urticaria, glaucoma, diseases characterized by disordered intestinal motion, sexual impotence, nephritis, cachexia, pancreatitis, post-PTCA reconstriction, etc. In said formula (I), Nu represents a 5- or 6-membered aromatic ring; ch1 and ch2 represent each a cross-linking group; and A represents an aromatic ring.

公开(公告)号：EP0995742A4

公开(公告)日：2004-08-25

申请号：EP98929715

申请日：1998-06-24

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： KAYAKIRI HIROSHI ,  ABE YOSHITO ,  HAMASHIMA HITOSHI ,  SAWADA HITOSHI ,  MIZUTANI TSUYOSHI ,  YAMASAKI NORITSUGU ,  ONOMURA OSAMU ,  NISHIKAWA MASAHIRO ,  HIRAMURA TAKAHIRO ,  OKU TERUO ,  IMOTO TAKAFUMI

IPC分类号： G06Q50/10 ,  A61K20060101 ,  A61K31/381 ,  A63B69/36 ,  C07D20060101 ,  C07D215/48 ,  C07D231/56 ,  C07D239/96 ,  C07D241/52 ,  C07D249/18 ,  C07D307/79 ,  C07D333/54 ,  C07D333/56 ,  C07D333/62 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F20060101 ,  A61K31/34 ,  A61K31/38 ,  A61K31/415 ,  A61K31/437 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  C07D235/26

CPC分类号： C07D241/52 ,  C07D215/48 ,  C07D231/56 ,  C07D239/96 ,  C07D249/18 ,  C07D307/79 ,  C07D333/54 ,  C07D333/62 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： Sulfonamide compounds represented by the general formula (I) R1-SO2NHCO-A-X-R2, salts thereof, and medicinal compositions containing the same. In said formula, R1 represents alkyl, alkenyl, alkynyl, etc.; A represents an optionally substituted polyheterocyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenz-imidazolyl and 2,3-dihydrobenzoxazinyl; X represents alkylene, oxygen, oxygenated lower alkylene, etc.; and R2 represents optionally substituted aryl, substituted biphenylyl, etc. These compounds are useful in treating diseases curable based on the hypoglycemic effect, and diseases curable based on the cGMP-PDE inhibitory, leiolytic, bronchodilating, vasodilating, smooth muscle cell inhibitory, and antiallergic effects.

公开(公告)号：EP1020452A4

公开(公告)日：2003-04-02

申请号：EP98929723

申请日：1998-06-26

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： YAMASAKI NORITSUGU ,  IMOTO TAKAFUMI ,  OKU TERUO ,  KATAYAMA AKIRA ,  KAYAKIRI HIROSHI ,  ONOMURA OSAMU ,  HIRAMURA TAKAHIRO ,  NISHIKAWA MASAHIRO ,  SAWADA HITOSHI

IPC分类号： A61K31/4184 ,  A61K31/4725 ,  A61P3/10 ,  C07D235/08 ,  C07D401/06 ,  C07D405/10 ,  C07D409/10 ,  C07D409/12 ,  A61K31/415 ,  A61K31/47 ,  C07D235/26 ,  C07D235/28

CPC分类号： C07D401/06 ,  C07D235/08 ,  C07D405/10 ,  C07D409/10 ,  C07D409/12

摘要： New benzimidazole derivatives of general formula (I) or salts thereof, useful as medicines, wherein R1 is alkyl or the like; R2 is aromatic ring-containing lower alkyl which may be substituted; R3 is alkyl or the like; and -X- is a group of general formula (V) or the like.

摘要翻译： 可用作药物的通式（I）的新的苯并咪唑衍生物或其盐，其中R 1为烷基等; R2是可被取代的含芳环的低级烷基; R3是烷基等; 并且-X-是通式（V）的基团等。