专利检索 ap:("FUJISAWA PHARMACEUTICAL CO" OR "DAICEL CHEM") AND inv:"DOHTSU KUNIHIKO" 第 1 页

1.

发明公开
CRYSTALLINE FORMS OF 3-(2,4-DICHLOROBENZYL)-2-METHYL-N-(PENTYLSULFONYL)-3H-BENZIMIDAZOLE-5-CARBOXAMIDE 审中-公开
标题翻译： 3-（2,4-二氯苄基）-2-甲基-N-（戊基磺酰基）-3H-苯并咪唑-5-甲酰胺结晶形式

公开(公告)号：EP1138674A4

公开(公告)日：2002-08-21

申请号：EP99972205

申请日：1999-11-11

申请人： FUJISAWA PHARMACEUTICAL CO , DAICEL CHEM

发明人： MURAI YOSHIYUKI , YAMASAKI NORITSUGU , IMOTO TAKAFUMI , NISHIKAWA MASAHIRO , DOHTSU KUNIHIKO

IPC分类号： A61K31/404 , A61K31/415 , A61K31/4184 , A61P3/10 , A61P15/00 , C07D209/08 , C07D209/10 , C07D235/08

CPC分类号： A61K31/415 , A61K31/404 , C07D209/08 , C07D209/10 , C07D235/08

摘要： 3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide having a hypoglycemic activity or a PDE5 inhibitory effect occurs as three crystalline forms which are distinguishable from each other based on the powdery X-ray diffraction data. The most stable crystalline form thereof is useful as a bulk powder for drugs. Other crystalline forms comprise larger crystals, which can be very easily isolated by filtration and efficiently purified by crystallization, are useful in purifying 3-(2,4-dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide.