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1.发明公开New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them 失效喹唑啉衍生物，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0218999A2
公开(公告)日：1987-04-22
申请号：EP86113559.8
申请日：1986-10-02
发明人： Hashimoto, Masashi , Oku, Teruo , Ito, Yoshikuni , Namiki, Takayuki , Sawada, Kozo , Kasahara, Chiyoshi , Baba, Yukihisa
IPC分类号： C07D239/96 , C07D239/95 , C07D285/24 , C07D401/06 , C07D409/06 , A61K31/505
CPC分类号： C07D401/06 , C07D239/95 , C07D239/96 , C07D285/24 , C07D409/06
摘要： compound of the formula:
in which
R 1 and R 2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl,
R 3 is aryl or ar(lower)alkyl, both of which may have one or more suitable substituent(s), or heterocyclic(lower)alkyl,
R 4 is carboxy or protected carboxy,
A is oxygen or sulfur atom,
Y is carbonyl, thiocarbonyl or sulfonyl and
Z is lower alkylene,
and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them in admixture with pharmaceutically acceptable carriers.摘要翻译： 下式的化合物：...
...其中...... [R <1>和R <2>各自是氢，卤素，低级烷氧基或卤代（低级）烷基，...... [R <3>为芳基或芳（低级） 烷基，两者都可以具有一个或多个合适的取代基（一个或多个），或杂环（低级）烷基，...... [R <4>是羧基或保护的羧基，... A是氧或硫原子，... Y是羰基，硫代羰基或磺酰基 和... Z是低级亚烷基，......和它们的药学上可接受的盐，用于制备药物和它们的组成与药学上可接受的载体混合，其包括它们的方法。 -
2.发明授权New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them 失效新喹诺酮衍生物及其生产工艺及其包含的药物组合物
公开(公告)号：EP0218999B1
公开(公告)日：1991-02-06
申请号：EP86113559.8
申请日：1986-10-02
发明人： Hashimoto, Masashi , Oku, Teruo , Ito, Yoshikuni , Namiki, Takayuki , Sawada, Kozo , Kasahara, Chiyoshi , Baba, Yukihisa
IPC分类号： C07D239/96 , C07D239/95 , C07D285/24 , C07D401/06 , C07D409/06 , A61K31/505
CPC分类号： C07D401/06 , C07D239/95 , C07D239/96 , C07D285/24 , C07D409/06
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3.发明公开New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them 失效新喹诺酮衍生物及其生产工艺及其包含的药物组合物
公开(公告)号：EP0218999A3
公开(公告)日：1988-01-13
申请号：EP86113559
申请日：1986-10-02
发明人： Hashimoto, Masashi , Oku, Teruo , Ito, Yoshikuni , Namiki, Takayuki , Sawada, Kozo , Kasahara, Chiyoshi , Baba, Yukihisa
IPC分类号： C07D239/96 , C07D239/95 , C07D285/24 , C07D401/06 , C07D409/06 , A61K31/505
CPC分类号： C07D401/06 , C07D239/95 , C07D239/96 , C07D285/24 , C07D409/06
摘要： compound of the formula:
in which
R 1 and R 2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl, R 3 is aryl or ar(lower)alkyl, both of which may have one or more suitable substituent(s), or heterocyclic(lower)alkyl, R 4 is carboxy or protected carboxy, A is oxygen or sulfur atom, Y is carbonyl, thiocarbonyl or sulfonyl and Z is lower alkylene,
and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them in admixture with pharmaceutically acceptable carriers.
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