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    Quinolizinone compound, processes for preparation thereof and pharmaceutical composition comprising the same
    3.
    发明公开
    Quinolizinone compound, processes for preparation thereof and pharmaceutical composition comprising the same 失效
    Quinolizinon化合物，它们的制备方法和含有它们的药物组合物。

    公开(公告)号：EP0157346A2

    公开(公告)日：1985-10-09

    申请号：EP85103596.4

    申请日：1985-03-26

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Kitaura, Yoshihiko ,  Oku, Teruo ,  Hirai, Hideo ,  Yamamoto, Toshiyuki ,  Hashimoto, Masashi

    IPC分类号： C07D455/02 ,  C07D455/06 ,  C07D455/04 ,  C07D221/04 ,  A61K31/435

    CPC分类号： C07D455/00 ,  C07D455/02 ,  C07D455/04 ,  C07D455/06 ,  C07F7/1856 ,  Y02P20/55

    摘要： A compound of the formula:
    wherein

    R 1 is carboxy, amidated carboxy, cyano, thiocarbamoyl or tetrazolyl group;
    R 7 is hydrogen or aryl;
    R 2 is hydrogen, hydroxy, lower alkyl or lower alkoxy;
    R 3 is hydrogen, hydroxyl, lower alkyl, lower alkoxy, lower alkenyloxy, aryl which may have suitable substituent(s), arylthio, aroyl, ar(lower)alkyl, arenesulfonyl, arylamino which may have a suitable substituent or aryloxy; and
    R 2 and R 3 can be located at any place on the quinolizinone ring and can be linked together to form -CH 2 CH 2 CH 2 -, -CH = CH- or -CH = CH-CH = CH-; and pharmaceutically acceptable salts thereof, processes for preparing them and pharmaceutical compositions comprising them in association with the pharmaceutically acceptable, substantially non-toxic carrier or excipient.

    摘要翻译： 下式的化合物：... ... worin ...... [R <1>的羧基，酰胺化的羧基，氰基，硫代氨基甲酰基或四唑基; ... [R <7>是氢或芳基;氢...ř<2>是，羟基， 低级烷基或低级烷氧基; ... R 3是氢，羟基，低级烷基，低级烷氧基，低级链烯氧基，可具有适宜取代基（一个或多个）的芳基，芳硫基，芳酰基，芳（低级）烷基，芳烃磺酰基，芳基氨基可以具有合适的 取代基或芳氧基; 和...... [R <2>和R <3>可以在quinolizinone环上的任何地方并且位于可连接在一起以形成-CH2CH2CH2-，--CH.dbd.CH--或-CH = CH-CH = CH;和... 药学上可接受的盐，用于制备它们和药物组合物坠落在与药学上可接受的，基本上无毒的载体或赋形剂缔合撬它们。