专利检索 ap:("FUNDACAO OSWALDO CRUZ (FIOCRUZ)") AND inv:"SIQUEIRA, Isadora, C., Centro de Pesquisas Goncalo" 第 1 页

1.

发明授权
PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES 有权
标题翻译： IN本具有重复细菌-Ig样（BIG）结构域钩端螺旋体种蛋白质

公开(公告)号：EP1514104B1

公开(公告)日：2007-10-03

申请号：EP02807433.4

申请日：2002-05-20

申请人： FUNDACAO OSWALDO CRUZ (FIOCRUZ)

发明人： KO, Albert, I., C. de Pesquisas Gonçalo Moniz/Fio. , GALVAO REIS, Mitermayer, Centro de Pesquisas , ROSA CRODA, Julio, H., Centro de Pesquisas , SIQUEIRA, Isadora, C., Centro de Pesquisas Goncalo , HAAKE, David, A. , MATSUNAGA, James , RILEY, Lee, W. , BAROCCHI, Michele , YOUNG, Tracy, A.

IPC分类号： G01N33/53 , C07K17/00

CPC分类号： C07K14/20 , A61K38/00 , A61K39/00 , C07K16/1207 , G01N33/56911 , G01N33/6854 , G01N2333/20 , Y02A50/48 , Y02A50/56

摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.