公开(公告)号：EP2447278B1

公开(公告)日：2015-04-08

申请号：EP11178264.5

申请日：2003-10-10

申请人： Cornell Research Foundation, Inc.

发明人： Chang, Yung-Fu ,  Palaniappan, Raghavan U.M.

IPC分类号： C07K14/20

CPC分类号： G01N33/56911 ,  A61K39/00 ,  C07K14/20 ,  G01N2333/20 ,  G01N2469/10 ,  G01N2469/20 ,  Y02A50/48 ,  Y02A50/56

摘要： The invention provides novel immunogenic proteins LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits.

公开(公告)号：EP2456891A1

公开(公告)日：2012-05-30

申请号：EP10802574.3

申请日：2010-07-26

申请人： Southwest Regional PCR, LLC

发明人： WOLCOTT, Randall D. ,  KENNEDY, John P. ,  DOWD, Scot E.

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6809 ,  C12Q1/689 ,  Y02A50/56 ,  Y02A50/57 ,  Y02A50/59 ,  C12Q2525/15 ,  C12Q2535/122 ,  C12Q2537/143 ,  C12Q2563/179

摘要： Microbial ecology of a specimen is evaluated using an approach (Level I) that utilizes nucleic acid amplification with specific gene primers that will identify panels of microorganisms and antibiotic-resistance factors generating a diagnostic report (optionally with quantification of each microorganism or antibiotic-resistance factor) and an approach (Level II) that utilizes universal or semi-universal primers to amplify conserved genes at a general or specific taxonomic level that are tagged specimen specifically using a genetic or chemical marker that is specific to the specimen from which it was derived, then sequencing the amplified products with highly-parallel, high-throughput technology to provide comprehensive sequences of the microbial population in the specimen followed by analysis of this sequence information and specific targeted information from Level I and/or Level II to generate a comprehensive analysis, interpretation, and/or diagnostic report.

公开(公告)号：EP2024497A2

公开(公告)日：2009-02-18

申请号：EP06828120.3

申请日：2006-12-19

申请人： Fundacao Oswaldo Cruz - Fiocruz

发明人： MEDEIROS, Marco, Alberto ,  DOS REIS, mitemayer, Galvão ,  DA SILVA, Éverton, Fagonde ,  MCBRIDE, Alan, John, Alexander ,  CRODA, Julio, Henrique, Rosa ,  RAMOS, João, Gabriel, Rosa ,  DELLAGOSTIN, Odir, Antônio ,  MCBRIDE, Flavia, Weykamp, Cruz ,  KO, Albert, Icksang

IPC分类号： C12N15/09 ,  G01N33/53 ,  A61K39/02 ,  C07K14/20

CPC分类号： C07K14/20 ,  G01N33/56911 ,  G01N2333/20 ,  G01N2469/20 ,  Y02A50/56

摘要： The present invention refers to isolated DNA (deoxyribonucleic acid) molecules that encode for LigA and LigB proteins. The invention further refers to the use of fragments of these proteins in the diagnosis, and formulation of vaccines for prevention of infections caused by Leptospira in humans and animals.

公开(公告)号：EP1697396A2

公开(公告)日：2006-09-06

申请号：EP04812120.6

申请日：2004-11-24

申请人： Argos Therapeutics, Inc.

发明人： TCHEREPANOVA, Irina

IPC分类号： C07H21/04 ,  A61K48/00

CPC分类号： A61K39/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  C12Q1/6865 ,  Y02A50/407 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466 ,  Y02A50/48 ,  Y02A50/56 ,  C12Q2525/173

摘要： A method of amplifying RNA to obtain RNA molecules that are predominantly in the sense orientation and essentially devoid of RNA molecules that are in the anti-sense orientation. A method of transfecting antigen presenting cells with a composition comprising sense RNA encoding immunogenic antigens and essentially devoid of antisense RNA and dsRNA is also provided as well as dendritic cells prepared according to the method.

公开(公告)号：EP1514104A1

公开(公告)日：2005-03-16

申请号：EP02807433.4

申请日：2002-05-20

申请人： FUNDACAO OSWALDO CRUZ (FIOCRUZ)

发明人： KO, Albert, I.,C. de Pesquisas Gonçalo Moniz/Fio. ,  GALVAO REIS, Mitermayer,Centro de Pesquisas ,  ROSA CRODA, Julio, H.,Centro de Pesquisas ,  SIQUEIRA, Isadora, C.,Centro de Pesquisas Goncalo ,  HAAKE, David, A. ,  MATSUNAGA, James ,  RILEY, Lee, W. ,  BAROCCHI, Michele ,  YOUNG, Tracy, A.

IPC分类号： G01N33/53 ,  C07K17/00

CPC分类号： C07K14/20 ,  A61K38/00 ,  A61K39/00 ,  C07K16/1207 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  Y02A50/48 ,  Y02A50/56

摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.

公开(公告)号：EP2078095B9

公开(公告)日：2013-07-24

申请号：EP07800165.8

申请日：2007-09-04

申请人： Österreichisches Rotes Kreuz Landesverband Oberösterreich

发明人： DANZER, Martin ,  POLIN, Helene ,  HOFER, Katja ,  FIEDLER, Brigitte ,  RADLER, Juliane ,  ROSENHAMMER, Katrin ,  ATZMÜLLER, Sabine ,  GABRIEL, Christian

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689 ,  Y02A50/56

公开(公告)号：EP2392669B1

公开(公告)日：2013-01-30

申请号：EP10306276.6

申请日：2010-11-19

申请人： Institut d'Enseignement Supérieur et de Recherche en Alimentation, Santé Animale, Sciences Agronomiques et de l'Environnement

发明人： Kodjo, Angeli ,  Djelouadji, Zoheira

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/689 ,  C12Q2600/156 ,  Y02A50/451 ,  Y02A50/56

公开(公告)号：EP2447278A1

公开(公告)日：2012-05-02

申请号：EP11178264.5

申请日：2003-10-10

申请人： Cornell Research Foundation, Inc.

发明人： Chang, Yung-Fu ,  Palaniappan, Raghavan U.M.

IPC分类号： C07K14/20

CPC分类号： G01N33/56911 ,  A61K39/00 ,  C07K14/20 ,  G01N2333/20 ,  G01N2469/10 ,  G01N2469/20 ,  Y02A50/48 ,  Y02A50/56

摘要： The invention provides novel immunogenic proteins LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits.

摘要翻译： 本发明提供了来自钩端螺旋体的新型免疫原性蛋白LigB，用于开发有效的疫苗和抗体，以及改进的诊断方法和试剂盒。

公开(公告)号：EP1514104B1

公开(公告)日：2007-10-03

申请号：EP02807433.4

申请日：2002-05-20

申请人： FUNDACAO OSWALDO CRUZ (FIOCRUZ)

发明人： KO, Albert, I., C. de Pesquisas Gonçalo Moniz/Fio. ,  GALVAO REIS, Mitermayer, Centro de Pesquisas ,  ROSA CRODA, Julio, H., Centro de Pesquisas ,  SIQUEIRA, Isadora, C., Centro de Pesquisas Goncalo ,  HAAKE, David, A. ,  MATSUNAGA, James ,  RILEY, Lee, W. ,  BAROCCHI, Michele ,  YOUNG, Tracy, A.

IPC分类号： G01N33/53 ,  C07K17/00

CPC分类号： C07K14/20 ,  A61K38/00 ,  A61K39/00 ,  C07K16/1207 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  Y02A50/48 ,  Y02A50/56

摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.

公开(公告)号：EP0788605A1

公开(公告)日：1997-08-13

申请号：EP96933797.0

申请日：1996-08-28

申请人： Packers Diagnostics Inc.

发明人： JOLLEY, Michael, E. ,  NIELSEN, Klaus, H.

IPC分类号： G01N33

CPC分类号： G01N33/56916 ,  G01N33/56911 ,  G01N33/5695 ,  G01N2333/23 ,  G01N2333/35 ,  G01N2400/50 ,  Y02A50/56

摘要： In a homogeneous immunoassay, fluorophore-conjugated lipopolysaccharide derived bacterial antigens are reacted with antibodies specific for the antigens. Quantitative detection of the formation of an immune complex is obtained by measuring the change in fluorescence polarization after complex formation. The reaction occurs quickly (less than two minutes to equilibrium), and involves the addition of only one reagent to a diluted serum specimen. The absence of a solid phase separation step eliminates false positive results and increases throughput.