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公开(公告)号：EP3786298A1
公开(公告)日：2021-03-03
申请号：EP20184168.1
申请日：2013-11-01
发明人： ANGEL, Matthew , ROHDE, Christopher
IPC分类号： C12N15/31 , C12N5/10 , C12N9/22 , C12Q1/68 , C12N15/63 , A61K38/46 , A61K31/7115 , A61K48/00 , A61P35/00 , A61P25/28 , A61P25/14
摘要： The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：EP3099801B1
公开(公告)日：2020-03-18
申请号：EP15743915.9
申请日：2015-01-30
发明人： ANGEL, Matthew , ROHDE, Christopher
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公开(公告)号：EP3500585A1
公开(公告)日：2019-06-26
申请号：EP17842152.5
申请日：2017-08-17
发明人： ANGEL, Matthew , ROHDE, Christopher
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公开(公告)号：EP3099801A1
公开(公告)日：2016-12-07
申请号：EP15743915.9
申请日：2015-01-30
发明人： ANGEL, Matthew , ROHDE, Christopher
摘要： The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
摘要翻译： 本发明部分涉及核酸，包括编码蛋白质的核酸，包含核酸的治疗学和化妆品，将核酸递送至细胞，组织，器官和患者的方法，使用核酸诱导细胞表达蛋白质的方法 ，用于转染，基因编辑和重编程细胞的试剂盒和装置，以及使用这些方法，试剂盒和装置生产的细胞，生物体，治疗剂和化妆品。 描述了用于改变细胞DNA序列的方法和产物，以及使用合成的RNA分子（包括体内存在的细胞）诱导细胞表达蛋白质的方法和产物。 还描述了包含编码基因编辑蛋白的核酸的治疗剂。
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公开(公告)号：EP4249036A2
公开(公告)日：2023-09-27
申请号：EP22216417.0
申请日：2015-01-30
发明人： ANGEL, Matthew , ROHDE, Christopher
IPC分类号： A61M37/00
摘要： The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：EP3835420A1
公开(公告)日：2021-06-16
申请号：EP20211670.3
申请日：2012-12-05
发明人： ANGEL, Matthew , ROHDE, Christopher
IPC分类号： C12N9/22
摘要： The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：EP3690056A1
公开(公告)日：2020-08-05
申请号：EP20161924.4
申请日：2015-01-30
发明人： ANGEL, Matthew , ROHDE, Christopher
摘要： The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：EP4249036A3
公开(公告)日：2023-10-25
申请号：EP22216417.0
申请日：2015-01-30
发明人： ANGEL, Matthew , ROHDE, Christopher
摘要： The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：EP4149252A2
公开(公告)日：2023-03-22
申请号：EP21803274.6
申请日：2021-05-12
IPC分类号： A01K67/027 , A61K35/12 , G01N33/569
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公开(公告)号：EP4142744A1
公开(公告)日：2023-03-08
申请号：EP21795677.0
申请日：2021-04-28
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