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1.发明公开CHEWING GUM TABLET AND METHOD OF DOSING PHARMACEUTICALLY ACTIVE INGREDIENTS IN SUCH CHEWING GUM TABLET 有权咀嚼药物活性成分剂量的口香糖片和方法，这种口香糖片
公开(公告)号：EP2229156A1
公开(公告)日：2010-09-22
申请号：EP07846431.0
申请日：2007-12-20
申请人： Fertin Pharma A/S
CPC分类号： A61K9/0058 , A61K8/02 , A61K9/205 , A61K31/155 , A61Q11/00
摘要： The invention relates to a method of dosing pharmaceutically active ingredients in a compressed chewing gum tablet, the method comprising the steps of: providing one or more pharmaceutically active ingredients, mixing a chewing gum composition comprising said one or more pharmaceutically active ingredients and chewing gum granules, said chewing gum granules comprising gum base, and dosing said chewing gum composition to obtain a desired weight of the chewing gum composition and thereby obtaining a desired dose of said pharmaceutically active ingredient in the chewing gum tablet.
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公开(公告)号：EP2442668B1
公开(公告)日：2016-08-10
申请号：EP09776165.4
申请日：2009-06-19
申请人： Fertin Pharma A/S
IPC分类号： A23G4/08 , A23G4/12 , A61K9/00 , A61K31/465 , A23G4/06
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公开(公告)号：EP2229157A1
公开(公告)日：2010-09-22
申请号：EP07846432.8
申请日：2007-12-20
申请人： Fertin Pharma A/S
CPC分类号： A61K9/2072 , A23G4/043 , A23G4/12 , A23G4/20 , A61K9/0058 , A61K9/146 , A61K9/2077 , A61K9/2086 , A61K31/465 , A61K38/00
摘要： The invention relates to a compressed chewing gum tablet comprising at least a first and a second chewing gum module, said first chewing gum module comprising a first chewing gum composition comprising at least a first active ingredient and chewing gum granules containing gum base, said second chewing gum module comprising a second chewing gum composition comprising at least a second active ingredient and chewing gum granules containing gum base, wherein said first active ingredient is a pharmaceutically active ingredient, and said second active ingredient is selected from the group consisting of pharmaceutically active ingredients and enhancers, wherein the gum base content of said first and second chewing gum modules is different.
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4.发明授权CHEWING GUM TABLET AND METHOD OF DOSING PHARMACEUTICALLY ACTIVE INGREDIENTS IN SUCH CHEWING GUM TABLET 有权咀嚼药物活性成分剂量的口香糖片和方法，这种口香糖片
公开(公告)号：EP2229156B1
公开(公告)日：2016-11-09
申请号：EP07846431.0
申请日：2007-12-20
申请人： Fertin Pharma A/S
CPC分类号： A61K9/0058 , A61K8/02 , A61K9/205 , A61K31/155 , A61Q11/00
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公开(公告)号：EP2442668A1
公开(公告)日：2012-04-25
申请号：EP09776165.4
申请日：2009-06-19
申请人： Fertin Pharma A/S
IPC分类号： A23G4/08 , A23G4/12 , A61K9/00 , A61K31/465 , A23G4/06
摘要： The invention relates to a chewing gum composition with high pH-release, the chewing gum composition comprising an insoluble gum base matrix and a soluble bulk portion, wherein the gum base matrix and the bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion. Furthermore, the invention relates to a method of producing a chewing gum core, wherein a gum base matrix and a bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion, and the gum base matrix comprises a first amount of buffer from 2 to 20 percent by weight of the gum base matrix before mixing with the bulk portion. Finally, the invention relates to a gum base pellet comprising a water insoluble gum base matrix wherein the gum base pellet comprises a first amount of buffer.
摘要翻译： 本发明涉及具有高pH释放的咀嚼型胶基糖组合物，咀嚼型胶基糖组合物包含不溶性胶基基质和可溶性松散部分，其中将胶基基质和松散部分混合并挤出以形成最终咀嚼型胶基糖芯 并且其中胶基基质在与大块部分混合之前被缓冲。 此外，本发明涉及一种生产口香糖芯的方法，其中将胶基基质和本体部分混合并挤出以形成最终口香糖芯，并且其中胶基基质在与大块部分混合之前被缓冲 ，并且胶基基质包含在与大块部分混合之前占胶基基质重量2％至20％的第一量的缓冲剂。 最后，本发明涉及包含水不溶性胶基基质的胶基片，其中胶基片包含第一数量的缓冲剂。
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公开(公告)号：EP2229158B1
公开(公告)日：2016-08-10
申请号：EP07846433.6
申请日：2007-12-20
申请人： Fertin Pharma A/S
CPC分类号： A61K9/0058 , A61K9/2009 , A61K9/2086
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公开(公告)号：EP2229157B1
公开(公告)日：2016-08-10
申请号：EP07846432.8
申请日：2007-12-20
申请人： Fertin Pharma A/S
CPC分类号： A61K9/2072 , A23G4/043 , A23G4/12 , A23G4/20 , A61K9/0058 , A61K9/146 , A61K9/2077 , A61K9/2086 , A61K31/465 , A61K38/00
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公开(公告)号：EP2229158A1
公开(公告)日：2010-09-22
申请号：EP07846433.6
申请日：2007-12-20
申请人： Fertin Pharma A/S
CPC分类号： A61K9/0058 , A61K9/2009 , A61K9/2086
摘要： The invention relates to compressed chewing gum tablet comprising one or more pharmaceutically active ingredients and one or more enhancers, wherein the chewing gum tablet comprises at least one chewing gum module comprising a chewing gum composition, and wherein the chewing gum composition comprises chewing gum granules containing gum base, and wherein said enhancers are at least partly contained within at least a part of said chewing gum granules.
摘要翻译： 本发明涉及包含一种或多种药物活性成分和一种或多种增强剂的压缩口香糖片，其中所述口香糖片包含至少一种包含咀嚼型胶基糖组合物的咀嚼型胶基糖组合物，并且其中咀嚼型胶基糖组合物包含含有 胶基，并且其中所述增强剂至少部分地包含在所述口香糖颗粒的至少一部分内。
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