公开(公告)号：EP1742965B1

公开(公告)日：2012-10-24

申请号：EP05779251.7

申请日：2005-04-28

申请人： Fibrogen, Inc.

发明人： SPONG, Suzanne, M. ,  NEFF, Thomas, B. ,  KLAUS, Stephen, J.

IPC分类号： C07K14/475

CPC分类号： A61K39/395 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/22 ,  G01N33/57438 ,  G01N2333/475

公开(公告)号：EP1742965A2

公开(公告)日：2007-01-17

申请号：EP05779251.7

申请日：2005-04-28

申请人： FIBROGEN, INC.

发明人： SPONG, Suzanne, M. ,  NEFF, Thomas, B. ,  KLAUS, Stephen, J.

IPC分类号： C07K14/475

CPC分类号： A61K39/395 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/22 ,  G01N33/57438 ,  G01N2333/475

摘要： The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing pancreatic tumor survival, expansion, and metastasis. The invention also provides agents for use in the methods, particularly agents that reduce the level or activity of connective tissue growth factor (CTGF), and methods for identifying such agents.