公开(公告)号：EP1105051A1

公开(公告)日：2001-06-13

申请号：EP99943668.6

申请日：1999-08-10

申请人： FIBROGEN, INC.

发明人： YANG, Chunlin ,  POLAREK, James, W. ,  NEFF, Thomas, B.

IPC分类号： A61B17/04 ,  A61B17/08 ,  A61B17/12

CPC分类号： A61L24/102 ,  A61B17/00491 ,  A61B17/0057 ,  A61K38/00 ,  A61L15/325 ,  A61L24/043 ,  A61L24/104 ,  C07K14/78

摘要： Polymerized type I and/or III collagen based compositions for medical use as vascular sealants and wound dressings, and the preparation thereof, are described. Prior to polymerization, the collagen monomers are prepared recombinantly whereby chemical modifications of the collagen are not needed to form such monomers. The type I and/or III collagen compositions, which include gelatin comprised of type I and type III collagens, are useful as medical adhesives for bonding soft tissues and as sealants for a variety of medical uses. In a further aspect of the present invention, the polymerized type I and/or III collagen compositions include agents which induce wound healing or provide for additional beneficial characteristics desired in a tissue sealant or wound dressing. The compositions of the present invention are also useful in non-adhesive form.

公开(公告)号：EP2822545A2

公开(公告)日：2015-01-14

申请号：EP13758366.2

申请日：2013-03-08

申请人： Fibrogen, Inc.

发明人： LIN, Al, Y. ,  NEFF, Thomas, B. ,  YU, Kin-Hung

IPC分类号： A61K31/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/472 ,  A61K45/06 ,  C07D217/26 ,  A61K2300/00

摘要： The present invention provides a method for treatment of high cholesterol by reducing low density lipoprotein cholesterol (LDL-C) and/or very low density Opoproiein cholesterol (VLDL-C) in subjects In need thereof by administering a compound that inhibits HIF hydroxylase activity. The method is useful, for reducing LDL cholesterol levels and total cholesterol levels even In subjects already undergoing treatment with other cholesterol-lowering medications, for example statins, fibrates, nicotinic acids and bile acid-binding resins, and in patients having chronic kidney disease or end stage renal disease,
inter alia.

公开(公告)号：EP2341904A1

公开(公告)日：2011-07-13

申请号：EP09789222.8

申请日：2009-08-26

申请人： Fibrogen, Inc.

发明人： KLAUS, Stephen, J. ,  NEFF, Thomas, B. ,  WALKINSHAW, Gail ,  CHOW, Aisha

IPC分类号： A61K31/352 ,  A61K31/465 ,  A61K45/06 ,  A61P25/28

CPC分类号： A61K45/06 ,  A61K31/352 ,  A61K31/465 ,  A61K2300/00

摘要： The present invention relates to methods and compounds useful for treating multiple sclerosis.

公开(公告)号：EP1487472A2

公开(公告)日：2004-12-22

申请号：EP02797195.1

申请日：2002-12-06

申请人： FIBROGEN, INC.

发明人： GUENZLER-PUKALL, Volkmar ,  NEFF, Thomas, B. ,  WANG, Qingjian ,  AREND, Michael P. ,  FLIPPIN, Lee, A.

IPC分类号： A61K38/00 ,  C12N15/09 ,  C12Q1/56 ,  C12Q1/34

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

公开(公告)号：EP1232181B1

公开(公告)日：2013-03-27

申请号：EP00978455.4

申请日：2000-11-10

申请人： Fibrogen, Inc.

发明人： CHANG, Robert, C. ,  KIVIRIKKO, Kari, I. ,  NEFF, Thomas, B. ,  OLSEN, David, R. ,  POLAREK, James, W.

IPC分类号： A23L1/0562 ,  C07K14/78 ,  A61K47/42 ,  A61K8/65 ,  A61Q19/00 ,  C08H1/06 ,  C08L89/06 ,  G03C1/047 ,  A61K9/00

CPC分类号： C07K14/78 ,  A23L29/284 ,  A61K8/65 ,  A61K9/0014 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/42 ,  A61K2800/86 ,  A61Q19/00 ,  C08H1/06 ,  C08L89/06 ,  G03C1/047

公开(公告)号：EP1463823B1

公开(公告)日：2013-03-06

申请号：EP02805548.1

申请日：2002-12-06

申请人： Fibrogen, Inc.

发明人： KLAUS, Stephen, J. ,  LIN, Al, Y. ,  NEFF, Thomas, B. ,  WANG, Qingjian ,  GUENZLER-PUKALL, Volkmar ,  AREND, Michael, P. ,  FLIPPIN, Lee, A.

IPC分类号： A61K31/00 ,  A61K31/17 ,  C07K14/47 ,  C07K14/505 ,  A61K31/47 ,  A61K31/4738 ,  A61K31/63 ,  G01N33/74 ,  A61K38/17 ,  C12N15/09 ,  C12Q1/34 ,  C12Q1/56 ,  A61P7/06

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

公开(公告)号：EP1631591B1

公开(公告)日：2011-12-21

申请号：EP04753822.8

申请日：2004-06-02

申请人： FIBROGEN, INC.

发明人： LIN, Ai, Y. ,  NEFF, Thomas, B. ,  OLIVER, Noelynn, A. ,  USINGER, William, R. ,  WANG, Qingjian ,  YEOWELL, David, A.

IPC分类号： C07K16/22

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.

摘要翻译： 本发明涉及结合CTGF的抗体。 抗体特别针对参与与纤维化相关的生物活性的CTGF的区域。 本发明还涉及使用抗体治疗与CTGF相关的疾病的方法，包括局部和全身纤维化疾病，包括肺，肝脏，心脏，皮肤和肾脏的疾病。

公开(公告)号：EP1742965A2

公开(公告)日：2007-01-17

申请号：EP05779251.7

申请日：2005-04-28

申请人： FIBROGEN, INC.

发明人： SPONG, Suzanne, M. ,  NEFF, Thomas, B. ,  KLAUS, Stephen, J.

IPC分类号： C07K14/475

CPC分类号： A61K39/395 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/22 ,  G01N33/57438 ,  G01N2333/475

摘要： The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing pancreatic tumor survival, expansion, and metastasis. The invention also provides agents for use in the methods, particularly agents that reduce the level or activity of connective tissue growth factor (CTGF), and methods for identifying such agents.

公开(公告)号：EP1232181A2

公开(公告)日：2002-08-21

申请号：EP00978455.4

申请日：2000-11-10

申请人： FibroGen, Inc.

发明人： CHANG, Robert, C. ,  KIVIRIKKO, Kari, I. ,  NEFF, Thomas, B. ,  OLSEN, David, R. ,  POLAREK, James, W.

IPC分类号： C07K14/78 ,  C12N15/12 ,  C12P21/02 ,  C07K16/18

CPC分类号： C07K14/78 ,  A23L29/284 ,  A61K8/65 ,  A61K9/0014 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/42 ,  A61K2800/86 ,  A61Q19/00 ,  C08H1/06 ,  C08L89/06 ,  G03C1/047

摘要： The present invention relates to recombinant gelatins and composiitions thereof, and methods of producing and using the same.

摘要翻译： 本发明涉及包含重组明胶的疫苗，涉及生产和使用这些疫苗的方法以及疫苗接种试剂盒。

公开(公告)号：EP1140964A2

公开(公告)日：2001-10-10

申请号：EP99966224.0

申请日：1999-12-14

申请人： UNIVERSITY OF MIAMI ,  FIBROGEN, INC.

发明人： GROTENDORST, Gary, R. ,  NEFF, Thomas, B.

IPC分类号： C07H21/00 ,  C07K14/475

CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/475

摘要： The present invention is directed to CTGF fragments comprising at least exon 4 or exon 5 of CTGF and having mitogenic activity. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the mitogenic activity of said CTGF fragments and to the compositions so identified.