专利检索 ap:("Five Prime Therapeutics, Inc." OR "Centocor Research & Development, Inc.") AND inv:"FINER, Jeffrey" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS FOR REGULATING COLLAGEN AND SMOOTH MUSCLE ACTIN EXPRESSION BY SERPINE2 审中-公开
标题翻译：组合物和方法用于调节胶原蛋白的表达及平滑肌肌动蛋白BY SERPIN2

公开(公告)号：EP2361093A2

公开(公告)日：2011-08-31

申请号：EP09810806.1

申请日：2009-11-25

申请人： Five Prime Therapeutics, Inc. , Centocor Research & Development, Inc.

发明人： BRACE, Arthur , SULLIVAN, Kathleen , FINER, Jeffrey , BOSCH, Elizabeth , BOYLE, Kathleen , WONG, Brian , PIERCE, Kristen , BHAWE, Kaumudi , DAS, Anuk , FARRELL, Francis , SIVAKUMAR, Pitchumani

IPC分类号： A61K38/57 , C07K14/81

CPC分类号： C07K14/811 , A61K38/57 , C07K16/38 , C07K2317/76

摘要： The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or α-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further provides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.