摘要:
Acoustophoretic devices for separating particles from a non-flowing host fluid are disclosed. The devices include a substantially acoustically transparent container and a separation unit, with the container being placed within the separation unit. An ultrasonic transducer in the separation unit creates a planar or multi-dimensional acoustic standing wave within the container, trapping particles disposed within the non-flowing fluid and causing them to coalesce or agglomerate, then separate due to buoyancy or gravity forces.
摘要:
An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles/secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.
摘要:
An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
摘要:
Devices (100) for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber (107), a fluid outlet at a top end of the acoustic chamber (114), a concentrate outlet at a bottom end of the acoustic chamber (116), and an inlet (112) on a first side end (122) of the acoustic chamber (107). An ultrasonic transducer (106) on a side wall of the acoustic chamber and reflector at the opposite side wall create a multi-dimensional acoustic standing wave in the acoustic chamber (107) that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet (114), and the particulates are collected via the concentrate outlet (116). The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
摘要:
An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.