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1.发明授权
公开(公告)号：EP2880015B1
公开(公告)日：2017-09-27
申请号：EP13755978.7
申请日：2013-08-01
申请人： Fondazione Istituto Italiano Di Tecnologia , The Regents of the University of California , Alma Mater Studiorum -Università di Bologna
发明人： DE VIVO, Marco , SCARPELLI, Rita , CAVALLI, Andrea , MIGLIORE, Marco , PIOMELLI, Daniele , HABRANT, Damien , FAVIA, Angelo
IPC分类号： C07C271/28 , C07C271/42 , C07C271/44 , C07C271/56 , C07C271/58 , A61K31/325 , A61P35/00
CPC分类号： C07C271/56 , C07C271/28 , C07C271/44 , C07C271/58 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
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2.发明授权DUAL INHIBITOR COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS AND ALZHEIMER'S DISEASE 有权双重抑制剂化合物用于治疗神经退行性疾病和阿尔茨海默病
公开(公告)号：EP3154953B1
公开(公告)日：2018-04-04
申请号：EP15731721.5
申请日：2015-06-12
发明人： CAVALLI, Andrea , PRATI, Federica , BOTTEGONI, Giovanni , FAVIA, Angelo Danilo , PIZZIRANI, Daniela , SCARPELLI, Rita , BOLOGNESI, Maria Laura
IPC分类号： C07D251/10 , A61K31/53
CPC分类号： C07D251/10 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.
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3.发明公开DUAL INHIBITOR COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS AND ALZHEIMER'S DISEASE 有权双重抑制剂化合物，其用在神经退行性故障的处理和阿尔茨海默氏病
公开(公告)号：EP3154953A1
公开(公告)日：2017-04-19
申请号：EP15731721.5
申请日：2015-06-12
发明人： CAVALLI, Andrea , PRATI, Federica , BOTTEGONI, Giovanni , FAVIA, Angelo Danilo , PIZZIRANI, Daniela , SCARPELLI, Rita , BOLOGNESI, Maria Laura
IPC分类号： C07D251/10 , A61K31/53
CPC分类号： C07D251/10 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.
摘要翻译： 本发明涉及药物组合物包含相同的式（I）的化合物和。 本发明还涉及它们在预防或治疗中枢神经系统疾病或障碍，特别是认知，神经变性或神经元疾病或病症的用途。
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4.发明授权PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR) 有权苯基氨基甲酸酯及其作为D3多巴明受体（D3DR）的脂肪酸酰胺水解酶（FAAH）酶和调节剂的抑制剂的用途
公开(公告)号：EP3022179B1
公开(公告)日：2017-11-15
申请号：EP14744009.3
申请日：2014-07-10
发明人： BOTTEGONI, Giovanni , DE SIMONE, Alessio , RUDA, Gian Filippo , CAVALLI, Andrea , BANDIERA, Tiziano , PIOMELLI, Daniele
IPC分类号： C07D209/88 , C07D211/38 , C07D213/30 , C07D295/125 , C07D295/13 , A61K31/495 , A61K31/496 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/30 , C07D211/14
CPC分类号： C07D295/13 , C07D209/88 , C07D211/14 , C07D211/38 , C07D213/30 , C07D295/125
摘要： The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar′, R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
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5.发明公开PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR) 有权苯基氨基甲酸酯以及它们作为脂肪酸酰胺水解酶抑制剂（FAAH）酶和多巴胺D 3受体的调节剂（D3DR）
公开(公告)号：EP3022179A1
公开(公告)日：2016-05-25
申请号：EP14744009.3
申请日：2014-07-10
发明人： BOTTEGONI, Giovanni , DE SIMONE, Alessio , RUDA, Gian Filippo , CAVALLI, Andrea , BANDIERA, Tiziano , PIOMELLI, Daniele
IPC分类号： C07D209/88 , C07D211/38 , C07D213/30 , C07D295/125 , C07D295/13 , A61K31/495 , A61K31/496 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/30
CPC分类号： C07D295/13 , C07D209/88 , C07D211/14 , C07D211/38 , C07D213/30 , C07D295/125
摘要： The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar′, R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
摘要翻译： 本发明提供了式（I）的化合物或其药学上可接受的盐其中Ar”，R1，R2，R3，R4，X，Y是如本发明的描述限定，并且多目标定向配体（MTDLs）并处于 脂肪酸酰胺水解酶的抑制剂的Sametime（FAAH）的酶和多巴胺D 3受体（D3DR）它们的制备，配方和灰以及它们的治疗应用的方法的调节剂。
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公开(公告)号：EP2880015A1
公开(公告)日：2015-06-10
申请号：EP13755978.7
申请日：2013-08-01
申请人： Fondazione Istituto Italiano Di Tecnologia , The Regents of the University of California , Alma Mater Studiorum -Universita' di Bologna
发明人： DE VIVO, Marco , SCARPELLI, Rita , CAVALLI, Andrea , MIGLIORE, Marco , PIOMELLI, Daniele , HABRANT, Damien , FAVIA, Angelo
IPC分类号： C07C271/28 , C07C271/42 , C07C271/44 , C07C271/56 , C07C271/58 , A61K31/325 , A61P35/00
CPC分类号： C07C271/56 , C07C271/28 , C07C271/44 , C07C271/58 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： The invention provides novel multitarget inhibitors of the enzymes Fatty Acid Amide Hydrolase (FAAH), Cyclooxygenase-1 (COX-1) and/or Cyclooxygenase-2 (COX-2) having a specific carbamate moiety on the meta or ortho position of the A ring of a substituted biphenyl core and having an halogen in the ortho position of the B ring of the biphenyl core. The invention concerns also with therapeutical application of the multitarget inhibitors in particular in the prevention and treatment of cancer.
摘要翻译： 脂肪酸酰胺水解酶（FAAH），环氧合酶-1（COX-1）和/或环氧合酶-2（COX-2）的多靶抑制剂在取代的A环的间位或邻位上具有特定的氨基甲酸酯部分 联苯核心，在联苯核心的B环的邻位具有卤素。 还涉及多靶抑制剂的治疗应用，特别是预防和治疗癌症。
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7.发明公开STUDYING MOLECULAR INTERACTION VIA ENHANCED MOLECULAR DYNAMICS SIMULATIONS 审中-公开通过增强分子动力学模拟研究分子间相互作用
公开(公告)号：EP3180720A1
公开(公告)日：2017-06-21
申请号：EP15778018.0
申请日：2015-08-07
发明人： ROCCHIA, Walter , CAVALLI, Andrea
CPC分类号： G06F19/701 , G06F19/16 , G06F19/706
摘要： A method is disclosed for enhancing the simulation of the interaction between at least a first and a second molecular system, the interaction resulting from actual attraction and repulsion forces between the at least a first and a second molecular system. The method comprises applying an additional virtual electrostatic force between the at least a first and a second molecular system, which force has a functional form of the type of a modulated electrostatic interaction.
摘要翻译： 公开了一种用于增强至少第一分子系统与第二分子系统之间的相互作用的模拟的方法，该至少第一分子系统与第二分子系统之间的实际吸引力和排斥力引起的相互作用。 该方法包括在至少第一分子系统和第二分子系统之间施加额外的虚拟静电力，该力具有调制静电相互作用类型的功能形式。
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公开(公告)号：EP4073054A1
公开(公告)日：2022-10-19
申请号：EP20823960.8
申请日：2020-12-11
申请人： Fondazione Istituto Italiano di Tecnologia , Tes Pharma S.r.l. , Alma Mater Studiorum Universita di Bologna , Istituto Europeo di Oncologia S.r.l.
发明人： CAVALLI, Andrea , MILANO, Domenico , MANERBA, Marcella , BAGNOLINI, Greta , ORTEGA MARTINEZ, Jose Antonio , ROBERTI, Marinella , DI STEFANO, Giuseppina , PELLICCIARI, Roberto , DE FRANCO, Francesca , MINUCCI, Saverio , PELICCI, Pier Giuseppe , PREVITALI, Viola
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , A61K31/4709 , A61P35/00
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