公开(公告)号：EP4335499A3

公开(公告)日：2024-05-15

申请号：EP24150915.7

申请日：2019-05-14

申请人： Foresee Pharmaceuticals USA, Inc.

发明人： Yang, Wenjin ,  Chang, Kai-Wei ,  Liu, Suying ,  Tsai, Cheng-Han

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D409/04 ,  A61K31/4166 ,  A61P11/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D409/04 ,  A61P11/00

摘要： Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

公开(公告)号：EP4349332A3

公开(公告)日：2024-05-15

申请号：EP24150920.7

申请日：2019-05-14

申请人： Foresee Pharmaceuticals USA, Inc.

发明人： Yang, Wenjin ,  Chang, Kai-Wei ,  Liu, Suying ,  Tsai, Cheng-Han

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D409/04 ,  A61K31/4166 ,  A61P11/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D409/04 ,  A61P11/00

摘要： Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

公开(公告)号：EP4349332A2

公开(公告)日：2024-04-10

申请号：EP24150920.7

申请日：2019-05-14

申请人： Foresee Pharmaceuticals USA, Inc.

发明人： Yang, Wenjin ,  Chang, Kai-Wei ,  Liu, Suying ,  Tsai, Cheng-Han

IPC分类号： A61K31/4166

摘要： Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

公开(公告)号：EP4335499A2

公开(公告)日：2024-03-13

申请号：EP24150915.7

申请日：2019-05-14

申请人： Foresee Pharmaceuticals USA, Inc.

发明人： Yang, Wenjin ,  Chang, Kai-Wei ,  Liu, Suying ,  Tsai, Cheng-Han

IPC分类号： A61P11/00

摘要： Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.