专利检索 ap:("Forma TM, LLC." OR "Genentech, Inc.") AND inv:"GOSSELIN, Francis" 第 1 页

1.

发明授权
PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES 有权
标题翻译：吡啶基和嘧啶基亚砜和砜衍生物

公开(公告)号：EP2820017B1

公开(公告)日：2016-12-21

申请号：EP13754209.8

申请日：2013-03-01

申请人： GENENTECH, INC. , FORMA TM, LLC

发明人： BAIR, Kenneth W. , BAUMEISTER, Timm R. , DRAGOVICH, Peter , GOSSELIN, Francis , YUEN, Po-Wai , ZAK, Mark , ZHENG, Xiaozhang

IPC分类号： C07D471/04 , C07D491/04 , C07D497/04 , A61K31/4355 , A61K31/437 , A61P3/10 , A61P9/10 , A61P35/00 , A61P29/00

CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00

2.

发明公开
NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT 审中-公开
标题翻译： NEUS VERBINDUNGEN UND ZUSAMMENSETZUNGEN ZUR NAMPT-HEMMUNG

公开(公告)号：EP2611804A1

公开(公告)日：2013-07-10

申请号：EP11757483.0

申请日：2011-09-02

申请人： Forma TM, LLC. , Genentech, Inc.

发明人： BAIR, Kenneth, W. , BAUMEISTER, Timm , BUCKMELTER, Alexandre, J. , CLODFELTER, Karl, H. , DRAGOVICH, Peter , GOSSELIN, Francis , HAN, Bingsong , LIN, Jian , REYNOLDS, Dominic J. , ROTH, Bruce , SMITH, Chase, C. , WANG, Zhongguo , YUEN, Po-Wai , ZHENG, Xiaozhang

IPC分类号： C07D471/04 , C07D491/04 , C07D495/04 , A61K31/437 , A61P35/00

CPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04

摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

摘要翻译： 本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。本发明的说明性化合物如下所示：

3.

发明公开
PROCESS OF MAKING HYDROXYLATED CYCLOPENTAPYRIMIDINE COMPOUNDS AND SALTS THEREOF 审中-公开
标题翻译：用于生产羟基化CYCLOPENTAPYRIMIDINVERBINDUNGEN及其盐

公开(公告)号：EP2850200A1

公开(公告)日：2015-03-25

申请号：EP13725535.2

申请日：2013-05-17

申请人： Genentech, Inc.

发明人： BABU, Srinivasan , GOSSELIN, Francis , RAN, Yingqing , REMARCHUK, Travis , SAVAGE, Scott J. , STULTS, Jeffrey , YAJIMA, Herbert

IPC分类号： C12P17/16 , C07D403/04

CPC分类号： C07D239/70 , C07D403/04 , C12P17/165

摘要： The invention provides new processes for making and purifying salts of hydroxylated cyclopentapyrimidine compounds, which are useful as AKT inhibitors used in the treatment of diseases such as cancer, including the monohydrochloride salt of (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.

4.

发明公开
SYNTHESIS OF RESTRAINED COMPLEXING AGENTS 审中-实审

公开(公告)号：EP4423056A1

公开(公告)日：2024-09-04

申请号：EP22818156.6

申请日：2022-10-26

申请人： GENENTECH, INC.

发明人： WONG, Nicholas , GOSSELIN, Francis

IPC分类号： C07C229/16 , C07B59/00

CPC分类号： C07C227/08 , C07C2601/1420170501 , C07C227/16 , C07C227/18

5.

发明公开
PROCESS FOR THE PREPARATION OF BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS 审中-实审

公开(公告)号：EP4347574A1

公开(公告)日：2024-04-10

申请号：EP22732817.6

申请日：2022-05-27

申请人： Genentech, Inc.

发明人： ANGELAUD, Remy , BRUETSCH, Tobias , GOSSELIN, Francis , HAN, Chong , STUTZ, Alfred

IPC分类号： C07D263/20 , C07C311/05 , C07D498/04 , A61P35/00

6.

发明公开
PROCESSES FOR THE PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS 审中-公开

公开(公告)号：EP3656764A1

公开(公告)日：2020-05-27

申请号：EP19204562.3

申请日：2014-11-13

申请人： F. Hoffmann-La Roche AG , Genentech, Inc.

发明人： IDING, Hans , REENTS, Reinhard , SCALONE, Michelangelo , GOSSELIN, Francis

IPC分类号： C07D239/70 , A61K31/517 , C07C269/06 , C07C271/22 , C12P17/16

摘要： The present invention relates to a process for the preparation of a compound of formula (I)

wherein R 1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.

7.

发明授权
PROCESS FOR PREPARING A COMPOUND 有权

公开(公告)号：EP3036227B1

公开(公告)日：2020-01-08

申请号：EP14838336.7

申请日：2014-08-21

申请人： Genentech, Inc. , Array Biopharma Inc.

发明人： HAN, Chong , GREEN, Keena , GOSSELIN, Francis , SCALONE, Michelangelo , NICHOLS, Paul J. , LIU, Weidong , STENGEL, Peter J. , SHAKYA, Sagar , CRANE, Zackary D. , SPENCER, Keith L.

IPC分类号： C07D401/00 , C07D403/00

8.

发明公开
PROCESSES FOR THE PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS 审中-实审

公开(公告)号：EP4282973A3

公开(公告)日：2024-03-27

申请号：EP23182382.4

申请日：2014-11-13

申请人： F. Hoffmann-La Roche AG , GENENTECH, INC.

发明人： IDING, Hans , REENTS, Reinhard , SCALONE, Michelangelo , GOSSELIN, Francis

IPC分类号： C07D239/70 , A61K31/517 , C07C269/06 , C07C271/22 , C12P17/16 , A61P35/00 , A61P43/00

摘要： The present invention relates to a process for the preparation of a compound of formula (I)

wherein R 1 is as defined herein, which is useful as an intermediate in the preparation of active pharmaceutical compounds.

9.

发明公开
SOLID FORMS OF AN AKT INHIBITING PYRIMIDINYL-CYCLOPENTANE COMPOUND, COMPOSITIONS AND METHODS THEREOF 审中-公开

公开(公告)号：EP3719014A1

公开(公告)日：2020-10-07

申请号：EP20162228.9

申请日：2013-05-17

申请人： GENENTECH, INC.

发明人： CHAKRAVARTY, Paroma , KOTHARI, Sanjeev , GOSSELIN, Francis , SAVAGE, Scott J. , STULTS, Jeffrey

IPC分类号： C07D403/04 , A61K31/517

摘要： Disclosed is ( S )-2-(4-chlorophenyl)-1-(4-((5 R ,7 R )-7-hydroxy-5-methyl-6,7-dihydro-5 H -cyclopenta[ d ]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.

10.

发明公开
AMORPHOUS FORM OF AN AKT INHIBITING PYRIMIDINYL - CYCLOPENTANE COMPOUND, COMPOSITIONS AND METHODS THEREOF 审中-公开
标题翻译： AKT炎症嘧啶环戊烷-LINK组合物，其和方法的无定形形式

公开(公告)号：EP2858989A1

公开(公告)日：2015-04-15

申请号：EP13726362.0

申请日：2013-05-17

申请人： Genentech, Inc.

发明人： CHAKRAVARTY, Paroma , KOTHARI, Sanjeev , GOSSELIN, Francis , SAVAGE, Scott J. , STULTS, Jeffrey

IPC分类号： C07D403/04

摘要： Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.