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公开(公告)号：EP2820008B1
公开(公告)日：2016-12-14
申请号：EP13755811.0
申请日：2013-03-01
申请人： Genentech, Inc. , Forma TM, LLC.
发明人： BAIR, Kenneth, W. , BAUMEISTER, Timm, R. , DRAGOVICH, Peter , LIU, Xiongcai , PATEL, Snahel , ZAK, Mark , ZHAO, Guiling , ZHANG, Yamin , ZHENG, Xiaozhang
IPC分类号： C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
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公开(公告)号：EP2611778B1
公开(公告)日：2015-08-05
申请号：EP11757484.8
申请日：2011-09-02
申请人： Forma TM, LLC.
发明人： BAIR, Kenneth W. , BUCKMELTER, Alexandre J. , HAN, Bingsong , LIN, Jian , REYNOLDS, Dominic J. , SMITH, Chase C. , WANG, Zhongguo , ZHENG, Xiaozhang
IPC分类号： C07D213/74 , C07D401/04 , A61P35/00 , A61K31/437 , A61K31/4406
CPC分类号： C07D213/75 , A61K31/437 , A61K31/4406 , A61K31/4409 , A61K45/06 , C07D213/74 , C07D401/04 , C07D471/04
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3.发明公开GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT 有权AN AM VER EN EN T T T T T T T T T T T T T T T
公开(公告)号：EP2611778A1
公开(公告)日：2013-07-10
申请号：EP11757484.8
申请日：2011-09-02
申请人： Forma TM, LLC.
发明人： BAIR, Kenneth W. , BUCKMELTER, Alexandre J. , HAN, Bingsong , LIN, Jian , REYNOLDS, Dominic J. , SMITH, Chase C. , WANG, Zhongguo , ZHENG, Xiaozhang
IPC分类号： C07D213/74 , C07D401/04 , A61P35/00 , A61K31/437 , A61K31/4406
CPC分类号： C07D213/75 , A61K31/437 , A61K31/4406 , A61K31/4409 , A61K45/06 , C07D213/74 , C07D401/04 , C07D471/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.
摘要翻译： 本发明涉及抑制NAMPT，其合成，应用和解毒剂的化合物和组合物。 本发明的说明性化合物如下所示。
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公开(公告)号：EP2820008A4
公开(公告)日：2015-08-26
申请号：EP13755811
申请日：2013-03-01
申请人： GENENTECH INC , FORMA TM LLC
发明人： BAIR KENNETH W , BAUMEISTER TIMM R , DRAGOVICH PETER , LIU XIONGCAI , PATEL SNAHEL , ZAK MARK , ZHAO GUILING , ZHANG YAMIN , ZHENG XIAOZHANG
IPC分类号： C07D471/04 , A61K31/438 , A61K31/444 , A61K31/4545 , A61P35/00 , A61P35/02 , A61P35/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D519/00
CPC分类号： C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
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公开(公告)号：EP2820017A1
公开(公告)日：2015-01-07
申请号：EP13754209.8
申请日：2013-03-01
申请人： Genentech, Inc. , Forma TM, LLC.
发明人： BAIR, Kenneth W. , BAUMEISTER, Timm R. , DRAGOVICH, Peter , GOSSELI, Francis , YUEN, Po-Wai , ZAK, Mark , ZHENG, Xiaozhang
IPC分类号： C07D471/04 , C07D491/048 , C07D497/04 , A61K31/4355 , A61K31/437 , A61P3/10 , A61P9/10 , A61P35/00 , A61P29/00
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
摘要： Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
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6.发明公开4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL]AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER 有权4 - {[（吡啶-3-基甲基）氨基羰基]氨基} -BENZOLSULFONDERIVATE NAMPT ALS抑制剂用于治疗疾病如癌症
公开(公告)号：EP2611777A1
公开(公告)日：2013-07-10
申请号：EP11758024.1
申请日：2011-09-02
申请人： Forma TM, LLC. , Genentech, Inc.
发明人： BAIR, Kenneth W. , BAUMEISTER, Timm R. , BUCKMELTER, Alexandre J. , CLODFELTER, Karl H. , HAN, Bingsong , LIN, Jian , REYNOLDS, Dominic J. , SMITH, Chase C. , WANG, Zhongguo , ZHENG, Xiaozhang , YUEN, Po-Wai
IPC分类号： C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04 , C07C317/00 , A61K31/4406 , A61K31/4433 , A61K31/443 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/12 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07C317/42 , C07D213/40 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
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公开(公告)号：EP2820017B1
公开(公告)日：2016-12-21
申请号：EP13754209.8
申请日：2013-03-01
申请人： GENENTECH, INC. , FORMA TM, LLC
发明人： BAIR, Kenneth W. , BAUMEISTER, Timm R. , DRAGOVICH, Peter , GOSSELIN, Francis , YUEN, Po-Wai , ZAK, Mark , ZHENG, Xiaozhang
IPC分类号： C07D471/04 , C07D491/04 , C07D497/04 , A61K31/4355 , A61K31/437 , A61P3/10 , A61P9/10 , A61P35/00 , A61P29/00
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
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8.发明授权N-(4-{[PYRIDIN-3-YL-METHYL)CARBAMOYL]AMINO}BENZENE-SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER 有权4 - {[（吡啶-3-基甲基）氨基羰基]氨基} -BENZOLSULFONDERIVATE NAMPT ALS抑制剂用于治疗疾病如癌症
公开(公告)号：EP2611777B1
公开(公告)日：2016-05-11
申请号：EP11758024.1
申请日：2011-09-02
申请人： Forma TM, LLC. , Genentech, Inc.
发明人： BAIR, Kenneth W. , BAUMEISTER, Timm R. , BUCKMELTER, Alexandre J. , CLODFELTER, Karl H. , HAN, Bingsong , LIN, Jian , REYNOLDS, Dominic J. , SMITH, Chase C. , WANG, Zhongguo , ZHENG, Xiaozhang , YUEN, Po-Wai
IPC分类号： A61K45/06 , A61K31/437 , A61K31/44 , A61K31/4545 , A61K31/5377 , C07D401/12 , C07D317/42 , C07D213/40 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04 , A61K31/4406 , C07C317/42
CPC分类号： C07D401/12 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07C317/42 , C07D213/40 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04
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公开(公告)号：EP2820018A4
公开(公告)日：2015-09-02
申请号：EP13754380
申请日：2013-03-01
申请人： GENENTECH INC , FORMA TM LLC
发明人： BAIR KENNETH W , BAUMEISTER TIMM R , BUCKMELTER ALEXANDRE J , CLODFELTER KARL H , DRAGOVICH PETER , GUNZNER-TOSTE JANET , HAN BINGSONG , LIN JIAN , LIU XIONGCAI , REYNOLDS DOMINIC J , SMITH CHASE C , WANG ZHONGGUO , ZAK MARK , ZHANG YAMIN , ZHAO GUILING , ZHENG XIAOZHANG , YUEN PO-WAI
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , C07D491/04 , C07D495/04
CPC分类号： C07D519/00 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/496 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/551 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：EP2820017A4
公开(公告)日：2015-08-05
申请号：EP13754209
申请日：2013-03-01
申请人： GENENTECH INC , FORMA TM LLC
发明人： BAIR KENNETH W , BAUMEISTER TIMM R , DRAGOVICH PETER , GOSSELIN FRANCIS , YUEN PO-WAI , ZAK MARK , ZHENG XIAOZHANG
IPC分类号： C07D471/04 , A61K31/4355 , A61K31/437 , A61P3/10 , A61P9/10 , A61P29/00 , A61P35/00 , C07D491/04 , C07D497/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
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