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公开(公告)号：EP3201185B1
公开(公告)日：2018-11-21
申请号：EP15771465.0
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, Jr., David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D417/14 , A61P35/00 , A61K31/4704 , A61K31/4709
CPC分类号： C07D401/12 , A61K31/4704 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
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公开(公告)号：EP3447050B1
公开(公告)日：2020-02-19
申请号：EP18198969.0
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, David R. Jr., , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/12 , A61P35/00 , A61K31/4704 , A61K31/4709 , C07D215/227 , C07D471/04 , C07D405/12 , C07D409/12
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3.发明公开PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS 审中-公开吡啶-2（1H）酮喹啉酮衍生物作为突变体 - 离心脱氢酶抑制剂
公开(公告)号：EP3194376A1
公开(公告)日：2017-07-26
申请号：EP15778433.1
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/12 , A61P35/00 , A61K31/4704 , A61K31/4709 , C07D471/04 , C07D401/14
CPC分类号： C07D401/12 , A61K31/47 , C07D401/14 , C07D471/04
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
摘要翻译： 其中A，U，W1，W2，W3，R1-R6和R9在本文中描述。
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4.发明公开PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS 有权苯基喹啉酮衍生物作为突变 - 脱碳酸脱氢酶抑制剂
公开(公告)号：EP3194375A1
公开(公告)日：2017-07-26
申请号：EP15771464.3
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/12 , A61P35/00 , A61K31/4704 , A61K31/4709 , C07D215/227 , C07D471/04 , C07D405/12 , C07D409/12
CPC分类号： C07D215/227 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R8 are described herein.
摘要翻译： 本发明涉及用于治疗细胞增殖性疾病和癌症的具有新形态活性的突变异柠檬酸脱氢酶（mt-IDH）蛋白的抑制剂，其具有下式：其中A，B，W 1，W 2，W 3和R 1 -R 8是 在此描述。
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公开(公告)号：EP3194376B1
公开(公告)日：2018-10-24
申请号：EP15778433.1
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, Jr., David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/12 , A61P35/00 , A61K31/4704 , A61K31/4709 , C07D471/04 , C07D401/14
CPC分类号： C07D401/12 , A61K31/47 , A61P35/00 , C07D401/14 , C07D471/04
摘要： where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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6.发明公开PYRIDINYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS 有权吡啶基喹啉酮衍生物作为突变体 - 脱碳酸脱氢酶抑制剂
公开(公告)号：EP3201185A1
公开(公告)日：2017-08-09
申请号：EP15771465.0
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D417/14 , A61P35/00 , A61K31/4704 , A61K31/4709
CPC分类号： C07D401/12 , A61K31/4704 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
摘要翻译： 本发明涉及用于治疗细胞增殖疾病和癌症的具有新形态活性的突变异柠檬酸脱氢酶（mt-IDH）蛋白抑制剂，其具有下式：其中A，B，U，V，Z，W1，W2，W3 和R1-R6在本文中描述。
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7.发明公开QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS 审中-公开喹诺酮嘧啶类组合物作为突变型 - 离心脱氢酶抑制剂
公开(公告)号：EP3194383A1
公开(公告)日：2017-07-26
申请号：EP15771463.5
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, David R. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.
摘要翻译： 本发明涉及用于治疗细胞增殖性疾病和癌症的具有新形态活性的突变异柠檬酸脱氢酶（mt-IDH）蛋白抑制剂，其具有下式：其中A，B，W 1，W 2，W 3和R 1 -R 6是 在此描述。
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8.发明公开
公开(公告)号：EP4257131A3
公开(公告)日：2024-01-10
申请号：EP23176702.1
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, David R. Jr. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D417/14 , A61P35/00 , A61K31/4704 , A61K31/4709
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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9.发明公开
公开(公告)号：EP4257131A2
公开(公告)日：2023-10-11
申请号：EP23176702.1
申请日：2015-09-18
发明人： ASHWELL, Susan , CAMPBELL, Ann-Marie , CARAVELLA, Justin Andrew , DIEBOLD, R. Bruce , ERICSSON, Anna , GUSTAFSON, Gary , LANCIA, David R. Jr. , LIN, Jian , LU, Wei , WANG, Zhongguo
IPC分类号： A61K31/4709
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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公开(公告)号：EP4215197A1
公开(公告)日：2023-07-26
申请号：EP22216450.1
申请日：2019-05-16
发明人： KELLY, Patrick F. , COLLIS, Alan , DAVIS, Jeff , WALKER, Duncan , ASHWELL, Susan , THOMSON, Blythe , WEI, Lu
IPC分类号： A61K31/4709 , A61K9/48 , A61P35/00 , A61P35/02
摘要： Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).
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