公开(公告)号：EP3799872A1

公开(公告)日：2021-04-07

申请号：EP20203216.5

申请日：2014-11-18

申请人： Forma Therapeutics, Inc.

发明人： BAIR, Kenneth W. ,  HERBERTZ, Torsten ,  KAUFFMAN, Goss Stryker ,  KAYSER-BRICKER, Katherine J. ,  LUKE, George P. ,  MARTIN, Matthew W. ,  MILLAN, David S. ,  SCHILLER, Shawn E.R. ,  TALBOT, Adam C.

IPC分类号： A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  A61P1/00 ,  A61P1/04 ,  A61P3/04 ,  A61P3/10 ,  A61P15/16 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00

摘要： The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I:

wherein W, X, Y, Z, R 1 , R 2 , R 5 , and R 8 are as described herein.