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公开(公告)号：EP3793997A1
公开(公告)日：2021-03-24
申请号：EP19728257.7
申请日：2019-05-16
IPC分类号： C07D471/04 , C07D487/04 , A61P25/28 , A61K31/4985
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2.发明公开3-ARYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS 审中-公开作为HDAC抑制剂的3-芳基-4-氨基 - 二环[4,5,0]羟基酸
公开(公告)号：EP3292116A1
公开(公告)日：2018-03-14
申请号：EP16704357.9
申请日：2016-02-02
发明人： ZHENG, Xiaozhang , NG, Pui Yee , HAN, Bingsong , THOMASON, Jennifer R. , ZABLOCKI, Mary-Margaret , LIU, Cuixian , DAVIS, Heather , RUDNITSKAYA, Aleksandra , LANCIA, David, Jr. , MILLAN, David S. , MARTIN, Matthew W.
IPC分类号： C07D403/06 , C07D413/06 , C07D243/14 , C07D267/12 , A61K31/551 , A61K31/553 , A61P35/00
CPC分类号： C07D267/14 , C07D243/14 , C07D267/12 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/107 , C07D493/08 , C07D495/10 , C07D498/04 , C07D498/08
摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
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公开(公告)号：EP3799872A1
公开(公告)日：2021-04-07
申请号：EP20203216.5
申请日：2014-11-18
发明人： BAIR, Kenneth W. , HERBERTZ, Torsten , KAUFFMAN, Goss Stryker , KAYSER-BRICKER, Katherine J. , LUKE, George P. , MARTIN, Matthew W. , MILLAN, David S. , SCHILLER, Shawn E.R. , TALBOT, Adam C.
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K45/06 , A61P1/00 , A61P1/04 , A61P3/04 , A61P3/10 , A61P15/16 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00
摘要： The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I:
wherein W, X, Y, Z, R 1 , R 2 , R 5 , and R 8 are as described herein.-
4.发明公开3-ALKYL-4-AMIDO-BICYCLIC [4,5,0]HYDROXAMIC ACIDS AS HDAC INHIBITORS 审中-公开作为HDAC抑制剂的3-烷基-4-氨基 - 双环[4,5,0]羟基酸
公开(公告)号：EP3253747A1
公开(公告)日：2017-12-13
申请号：EP16706457.5
申请日：2016-02-02
发明人： ZHENG, Xiaozhang , NG, Pui Yee , HAN, Bingsong , THOMASON, Jennifer R. , ZABLOCKI, Mary-Margaret , LIU, Cuixian , DAVIS, Heather , RUDNITSKAYA, Aleksandra , LANCIA JR., David , BAIR, Kenneth W. , MILLAN, David S. , MARTIN, Matthew W.
IPC分类号： C07D403/06 , C07D413/06 , C07D243/14 , C07D267/12 , A61K31/551 , A61K31/553 , A61P35/00
CPC分类号： C07D267/14 , C07D243/14 , C07D267/12 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/107 , C07D493/08 , C07D495/10 , C07D498/04 , C07D498/08
摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC,
e.g ., HDAC6, having a Formula I:, where R, L, X
1 , X
2 , X
3 , X
4 , Y
1 , Y
2 , Y
3 , and Y
4 are described herein.-
公开(公告)号：EP3692028A1
公开(公告)日：2020-08-12
申请号：EP18864076.7
申请日：2018-10-05
发明人： CARAVELLA, Justin , HAN, Bingsong , LIU, Cuixian , IOANNIDIS, Stephanos , BUCKMELTER, Alexandre Joseph , RICHARD, David James , MARTIN, Matthew W. , MISCHKE, Steven , MENTE, Scot
IPC分类号： C07D401/06 , C07D471/04
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6.发明公开
公开(公告)号：EP3268358A1
公开(公告)日：2018-01-17
申请号：EP16711758.9
申请日：2016-03-11
发明人： BAIR, Kenneth W. , BARCZAK, Nicholas , HAN, Bingsong , LANCIA, David R., Jr. , LIU, Cuixian , MARTIN, Matthew W. , NG, Pui Yee , RUDNITSKAYA, Aleksandra , THOMASON, Jennifer R. , ZABLOCKI, Mary-Margaret , ZHENG, Xiaozhang
IPC分类号： C07D401/14 , C07D213/75 , C07C259/06 , A61P35/00 , C07D213/81 , C07D215/12 , C07C275/30 , C07D317/68 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D333/70 , C07D233/68 , C07D401/04
CPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10 , Y02A50/393 , Y02A50/411 , Y02A50/481
摘要： The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
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公开(公告)号：EP4218934A1
公开(公告)日：2023-08-02
申请号：EP23165482.3
申请日：2019-10-04
发明人： BUCKMELTER, Alex J. , CARAVELLA, Justin Andrew , LI, Hongbin , MARTIN, Matthew W. , MISCHKE, Steven , RICHARD, David James , WEST, Angela V.
IPC分类号： A61P35/02 , C07D401/14 , C07D403/12 , C07D413/14 , C07D471/08 , C07D487/08 , C07D487/18 , C07D491/107 , A61K31/506
摘要： The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.
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8.发明公开
公开(公告)号：EP3873214A1
公开(公告)日：2021-09-08
申请号：EP19880498.1
申请日：2019-10-29
发明人： LUKE, George, P. , HUBBS, Stephen , MARTIN, Matthew W. , SCHILLER, Shawn E.R. , WENSLOW, Robert , SHI, Yawei , HUANG, Jun
IPC分类号： A01N57/00 , A61K31/665
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公开(公告)号：EP3860989A1
公开(公告)日：2021-08-11
申请号：EP19791136.5
申请日：2019-10-04
发明人： BUCKMELTER, Alex J. , CARAVELLA, Justin Andrew , LI, Hongbin , MARTIN, Matthew W. , MISCHKE, Steven , RICHARD, David James , WEST, Angela V.
IPC分类号： C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14 , C07D487/08 , A61K31/4155 , A61K31/4439 , A61P25/00 , A61P25/16
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公开(公告)号：EP3587406A1
公开(公告)日：2020-01-01
申请号：EP19188403.0
申请日：2014-03-11
发明人： BAIR, Kenneth W. , LANCIA, David R., Jr. , LI, Hongbin , LOCH, James , LU, Wei , MARTIN, Matthew W. , MILLAN, David S. , SCHILLER, Shawn E.r , TEBBE, Mark J
IPC分类号： C07D295/192 , A61K31/496 , A61P35/00
摘要： The present invention relates to a list of specific 2-hydroxy-1-{4-[(4-phenylphenyl)carbonyl]piperazin-1-yl}ethan-1-one derivatives and related compounds as fatty acid synthase (FAS or FASN) inhibitors for treating cancer and pharmacutical compositions thereof .
An illustrative compound of the invention is shown below:
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