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    NOVEL ANTIMICROBIAL PEPTIDES
    2.
    发明公开
    NOVEL ANTIMICROBIAL PEPTIDES 有权
    新的抗微生物肽

    公开(公告)号：EP2271356A1

    公开(公告)日：2011-01-12

    申请号：EP09731331.6

    申请日：2009-04-07

    申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften

    发明人： BRANDENBURG, Klaus

    IPC分类号： A61K38/04 ,  C07K7/00

    CPC分类号： C07K14/43509 ,  A61K38/00

    摘要： The present invention relates to a peptide of linear, non-cyclic structure consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1 ) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking (23) G or lacking. Further, the invention relates to a nucleic acid molecule encoding the peptide of the invention, an expression vector comprising the nucleic acid molecule of the invention, a host cell which may be grown in cell culture comprising the vector of the invention, and a method of producing the peptide of the invention comprising culturing the host cell of the invention and collecting the peptide produced. Also, the present invention relates to a pharmaceutical composition comprising the peptide of the invention, the peptide produced by the method of the invention, the nucleic acid molecule of the invention, the expression vector of the invention or the host cell of the invention and a kit comprising the peptide of the invention, the peptide produced by the method of the invention, the nucleic acid molecule of the invention, the expression vector of the invention or the host cell of the invention.

    摘要翻译： 本发明涉及由17至23个氨基酸组成或包含17至23个氨基酸的线性非环状结构的肽，其中从N端计数的1至23位的氨基酸如下（1）G，S 或缺乏; （2）C或缺乏; （3）K或R; （4）K或R; （5）Y，W或F; （6）K或R; （7）K或R; （8）F，W或L; （9）K或R; （10）K或L或缺乏; （11）W，L或F; （12）K或R; （13）F，Y或C; （14）K或R; （15）G或Q; （16）K或R; （17）F，L或W; （18）F或W; （19）F，L或W; （20）W或F; （21）C或缺乏; （22）F或G或缺乏（23）G或缺乏。 此外，本发明涉及编码本发明的肽的核酸分子，包含本发明的核酸分子的表达载体，可以在包含本发明的载体的细胞培养物中生长的宿主细胞，以及 产生本发明的肽，包括培养本发明的宿主细胞并收集产生的肽。 而且，本发明涉及药物组合物，其包含本发明的肽，通过本发明的方法产生的肽，本发明的核酸分子，本发明的表达载体或本发明的宿主细胞和 试剂盒，其包含本发明的肽，通过本发明的方法产生的肽，本发明的核酸分子，本发明的表达载体或本发明的宿主细胞。