公开(公告)号：EP2902483B1

公开(公告)日：2020-03-11

申请号：EP13842351.2

申请日：2013-09-30

申请人： Foundation for Biomedical Research and Innovation at Kobe ,  Tokai University Educational System ,  Stemmed Inc. ,  Juntendo Educational Foundation

发明人： ASAHARA, Takayuki ,  MASUDA, Haruchika ,  TANAKA, Rika

IPC分类号： C12N5/077 ,  A61K35/14 ,  A61K35/28 ,  A61P3/10 ,  A61P9/10 ,  A61P17/02 ,  C12N5/078

公开(公告)号：EP2902483A1

公开(公告)日：2015-08-05

申请号：EP13842351.2

申请日：2013-09-30

申请人： Foundation for Biomedical Research and Innovation ,  Tokai University Educational System ,  Stemmed Inc. ,  Juntendo Educational Foundation

发明人： ASAHARA, Takayuki ,  MASUDA, Haruchika ,  TANAKA, Rika

IPC分类号： C12N5/077 ,  A61K35/14 ,  A61K35/28 ,  A61P3/10 ,  A61P9/10 ,  A61P17/02 ,  C12N5/078

摘要： Simplification of a preparation step of a cell population used for the treatment of ischemic diseases, and provision of a cell population that shows more effect by the treatment.
A method of producing a cell population wherein a vascular endothelial progenitor cell and/or an anti-inflammatory macrophage are/is enriched, including cultivating a mononuclear cell derived from bone marrow, cord blood or peripheral blood in a serum-free medium containing stem cell factor, interleukin-6, FMS-like tyrosine kinase 3 ligand, thrombopoietin and vascular endothelial cell growth factor, and proliferating vascular endothelial progenitor cell from the cell; and a cell population obtained by the method, etc.

摘要翻译： 简化用于治疗缺血性疾病的细胞群的制备步骤，以及提供通过治疗显示更多效果的细胞群。 一种生产细胞群的方法，其中富含血管内皮祖细胞和/或抗炎巨噬细胞，包括在含有干细胞的无血清培养基中培养源自骨髓，脐带血或外周血的单核细胞 因子，白介素-6，FMS样酪氨酸激酶3配体，血小板生成素和血管内皮细胞生长因子，以及来自细胞的增殖性血管内皮祖细胞; 和通过该方法得到的细胞群等