公开(公告)号：EP3229859B1

公开(公告)日：2019-02-06

申请号：EP15804319.0

申请日：2015-12-02

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WIENEKE, Paul ,  WOJKE, Ralf

IPC分类号： A61M1/36 ,  A61M1/16 ,  A61M1/34

公开(公告)号：EP3229859A1

公开(公告)日：2017-10-18

申请号：EP15804319.0

申请日：2015-12-02

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WOJKE, Ralf ,  WIENEKE, Paul

IPC分类号： A61M1/36 ,  A61M1/16 ,  A61M1/34

CPC分类号： A61M1/361 ,  A61M1/16 ,  A61M1/1603 ,  A61M1/1613 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/36 ,  A61M1/3612 ,  A61M1/3644 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3341 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2206/10 ,  A61M2206/11 ,  A61M2230/207

摘要： The invention relates to a dialysis machine having an extra-corporeal circuit in which there is a dialyzer, which has a blood-side chamber through which blood flows, and a first pressure sensor, located upstream of the blood-side chamber in the flow direction of the blood, for determining a first pressure value, and a second pressure sensor, located downstream of the blood-side chamber in the flow direction of the blood, for determining a second pressure value, wherein the dialysis machine has first means for determining the pressure difference between the second and the first pressure value, second means for determining the dynamic viscosity of the blood on the basis of the pressure difference determined, the blood flow rate through the blood-side chamber and one or more characteristic properties of the dialyzer, and third means for determining the hematocrit or the hemoglobin value of the blood on the basis of the viscosity determined, and wherein the dialysis machine has an open-loop or closed-loop control unit which is formed in such a way that said unit adjusts the blood flow rate and/or the dilution rate and/or the ultrafiltration rate in such a way that the time change of the hematocrit and/or of the hemoglobin value does not exceed a limiting value or lies within a set-point range.

摘要翻译： 透析器技术领域本发明涉及一种具有体外回路的透析机，其中存在透析器，该透析器具有供血液流过的血液侧腔室和位于血液侧腔室的流动方向上游的第一压力传感器 确定第一压力值;以及第二压力传感器，所述第二压力传感器位于所述血液流动方向上的所述血液侧室的下游，用于确定第二压力值，其中所述透析机具有用于确定 第二压力值与第一压力值之间的压差，第二装置，用于基于所确定的压力差，通过血液侧腔室的血流速度和透析器的一个或多个特性确定血液的动态粘度， 以及用于基于所确定的粘度来确定血液的血细胞比容或血红蛋白值的第三装置，并且其中透析机具有开放腔室 所述控制单元以这样的方式形成，即所述单元以这样的方式调整血流速率和/或稀释速率和/或超滤速率，使得血细胞比容和/或血细胞比容的时间变化 血红蛋白值不超过极限值或位于设定点范围内。

公开(公告)号：EP3177338A2

公开(公告)日：2017-06-14

申请号：EP15748179.7

申请日：2015-08-05

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WOJKE, Ralf ,  WIENEKE, Paul

IPC分类号： A61M1/36

CPC分类号： A61M1/3629 ,  A61M1/3626 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3365

摘要： The invention relates to a method for washing out gas bubbles from at least one target area of an extracorporeal blood circuit, preferably an extracorporeal blood circuit of a dialysis machine, with a rinsing fluid. The flow rate and/or the pressure of the rinsing fluid in the extracorporeal blood circuit during the rinsing process is at least intermittently inconsistent, and/or the flow rate of the rinsing fluid in the extracorporeal blood circuit during the rinsing process is situated at least temporarily above a range of possible flow rates, which is used during the treatment of the blood. The invention also relates to an extracorporeal blood treatment unit with an extracorporeal blood circuit, a pump and a control unit. Said control unit is designed to carry out an inventive rinsing method. The invention further relates to an extracorporeal blood treatment unit with an extracorporeal blood circuit, a pump and a control unit. Said control unit is designed such that after the pump has been at a standstill or after the pump has been operated at a throttled speed, the conveying speed for the blood is slowly increased.

摘要翻译： 本发明涉及一种用漂洗流体从体外血液回路的至少一个目标区域，优选透析机的体外血液回路洗出气泡的方法。 漂洗过程中体外血液回路中的漂洗液的流量和/或压力至少间歇地不一致，和/或漂洗过程中体外血液回路中漂洗液的流量至少位于 暂时超过在血液处理过程中使用的可能流量范围。 本发明还涉及具有体外血液回路的体外血液处理单元，泵和控制单元。 所述控制单元被设计成执行本发明的漂洗方法。 本发明还涉及一种具有体外血液回路的体外血液处理单元，泵和控制单元。 所述控制单元被设计为使得在泵已经停止或者在泵以节流速度运行之后，血液的传送速度缓慢增加。

公开(公告)号：EP3177358B1

公开(公告)日：2020-11-11

申请号：EP15748176.3

申请日：2015-08-04

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WOJKE, Ralf ,  WIENEKE, Paul

IPC分类号： A61M39/10 ,  F16L13/11 ,  F16L13/12 ,  F16L21/00 ,  F16L25/00 ,  F16L55/17 ,  A61M5/36

公开(公告)号：EP3177339B1

公开(公告)日：2020-09-30

申请号：EP15750245.1

申请日：2015-08-05

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WOJKE, Ralf ,  WIENEKE, Paul

IPC分类号： A61M1/36

公开(公告)号：EP3177340A1

公开(公告)日：2017-06-14

申请号：EP15753614.5

申请日：2015-08-05

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WOJKE, Ralf ,  WIENEKE, Paul

IPC分类号： A61M1/36

CPC分类号： A61M1/3627 ,  A61M1/3626 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3672 ,  A61M39/223 ,  A61M39/28 ,  A61M2205/3331 ,  A61M2205/3334

摘要： The invention relates to a method for washing out gas bubbles from a target area of an extracorporeal blood circuit of a dialysis machine, wherein a rinsing liquid flows through the target area, entering through an inlet into the target area and the same exiting through an outlet, wherein the inlet differs from the arterial port and the outlet differs from the venous port of the extracorporeal blood circuit. The invention further relates to a dialysis machine comprising an extracorporeal blood circuit and a control unit, wherein the extracorporeal blood circuit has an inlet and an outlet for rinsing fluid, wherein the inlet differs from the arterial port and the outlet differs from the venous port of the extracorporeal blood circuit, and wherein the control unit is designed to execute a method according to the invention. The invention further relates to a disposable for dialysis treatment, wherein the disposable comprises an arterial line, elements of a blood pump, a dialyzer and a venous line, wherein the disposable has an interface in the arterial line for the inlet of rinsing fluid and an interface in the venous line for the outlet of rinsing fluid, and wherein the interface for the inlet differs from the arterial port and the interface for the outlet differs from the venous port of the tube set.

摘要翻译： 本发明涉及一种用于从透析机的体外血液回路的目标区域中洗出气泡的方法，其中漂洗液体流过目标区域，通过入口进入目标区域并且通过出口 其中入口不同于动脉口并且出口不同于体外血液回路的静脉端口。 本发明还涉及包括体外血液回路和控制单元的透析机，其中体外血液回路具有用于冲洗流体的入口和出口，其中入口不同于动脉口，并且出口不同于 体外血液回路，并且其中控制单元被设计为执行根据本发明的方法。 本发明还涉及用于透析治疗的一次性用品，其中所述一次性用品包括动脉管路，血泵的元件，透析器和静脉管路，其中所述一次性管路具有用于冲洗流体入口的动脉管路中的接口和 在用于冲洗流体出口的静脉管路中接口，并且其中用于入口的接口不同于动脉口，并且用于出口的接口不同于管组的静脉端口。

公开(公告)号：EP3177339A1

公开(公告)日：2017-06-14

申请号：EP15750245.1

申请日：2015-08-05

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WOJKE, Ralf ,  WIENEKE, Paul

IPC分类号： A61M1/36

摘要： The invention relates to a method for cleaning an extracorporeal blood circuit, preferably an extracorporeal blood circuit of a dialysis machine, by means of a cleaning liquid, wherein the cleaning liquid contains an anticoagulative agent, preferably heparin. The invention further relates to an extracorporeal blood treatment unit, preferably a dialysis machine, comprising an extracorporeal blood circuit and a control unit, wherein the control unit is designed to carry out a cleaning method according to one of the preceding claims before the start of the treatment and/or intermittently during the treatment.

摘要翻译： 本发明涉及一种借助于清洁液来清洁体外血液回路，优选透析机的体外血液回路的方法，其中清洁液体含有抗凝剂，优选肝素。 本发明还涉及一种体外血液处理单元，优选透析机，其包括体外血液回路和控制单元，其中控制单元被设计为在开始之前执行根据前述权利要求中任一项所述的清洁方法 治疗期间和/或在治疗期间间歇性地进行。

公开(公告)号：EP3177340B1

公开(公告)日：2019-05-29

申请号：EP15753614.5

申请日：2015-08-05

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WOJKE, Ralf ,  WIENEKE, Paul

IPC分类号： A61M39/28 ,  A61M1/36 ,  A61M39/22

公开(公告)号：EP3229859B8

公开(公告)日：2019-04-17

申请号：EP15804319.0

申请日：2015-12-02

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WIENEKE, Paul ,  WOJKE, Ralf

IPC分类号： A61M1/36 ,  A61M1/16 ,  A61M1/34

公开(公告)号：EP3177358A1

公开(公告)日：2017-06-14

申请号：EP15748176.3

申请日：2015-08-04

申请人： Fresenius Medical Care Deutschland GmbH

发明人： WOJKE, Ralf ,  WIENEKE, Paul

IPC分类号： A61M39/10 ,  F16L13/11 ,  F16L13/12 ,  F16L21/00 ,  F16L25/00 ,  F16L55/17 ,  A61M5/36

摘要： The invention relates to a method for increasing the seal of a mechanical connector of an extracorporeal blood treatment machine. The mechanical connector has a pair of connection parts which have corresponding sealing surfaces. At least one of the two sealing surfaces is at least partly wetted with a viscous liquid prior to bringing together the connection parts, and/or the connection gap between the connection parts is covered with a casing after the connection parts are combined. The invention further relates to an extracorporeal blood treatment machine comprising a mechanical connector which has a pair of connection parts that have corresponding sealing surfaces. The sealing surfaces are at least partly wetted with a viscous liquid when the connector is closed, and/or the connection gap between the connection parts of the closed connector is covered with a casing.

摘要翻译： 本发明涉及一种用于增加体外血液处理机器的机械连接器的密封的方法。 机械连接器具有一对具有相应密封表面的连接部分。 在连接部件合在一起之前，两个密封表面中的至少一个密封表面至少部分地用粘性液体润湿，和/或在连接部件合并之后，连接部件之间的连接间隙被壳体覆盖。 本发明还涉及一种体外血液处理机器，其包括具有一对连接部分的机械连接器，所述连接部分具有对应的密封表面。 当连接器闭合时，密封表面至少部分被粘性液体润湿，和/或闭合连接器的连接部分之间的连接间隙被壳体覆盖。