摘要:
A medical apparatus and method of preparing one or more cell blocks. The medical apparatus comprises at least one elongate tubular body having a proximal end and a distal end and a filter membrane disposed between the proximal end and a distal end of the elongate tubular body. The filter membrane, which can include alignment features and structural features to engage the tubular body, and/or cover, is sectionable. In other embodiments, a valve is provided for opening and closing fluid communication with the filter membrane.
摘要:
Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.
摘要:
A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.
摘要:
A solution circuit apparatus (30) for a blood purification system (50) comprising an extracorporeal blood circuit (40) and the solution circuit apparatus (30), comprises: a solution source (1); a warmer (3) having a temperature sensor (8); a bypass branch (26); a delivery branch (25) communicating with the extracorporeal blood circuit (40); a pump (2); a switching means (5); and a control unit (39) configured to set the solution circuit apparatus (30) into one of a solution delivery condition and a solution stop condition. In the solution delivery condition the switching means (5) interrupts the bypass branch (26), and the pump (2) delivers solution via the warmer (3) and through the delivery branch (25). In the solution stop condition the switching means (5) interrupts the delivery branch (25), and the pump (2) recirculates solution through the warmer (3) via the bypass branch (26). In the therapy stop condition the pump rate is dependent on the output of the temperature sensor (8).
摘要:
Extracorporeal blood treatment apparatus and methods as described herein involve control of blood line pressure utilizing a non-invasive pressure sensor.
摘要:
A method comprising: receiving patient assessment information concerning one or more subjective characteristics of a patient; determining a patient assessment score based on the received patient assessment information; and modifying operation of a medical fluid treatment machine based on the patient assessment score.
摘要:
A method of predicting serum potassium concentrations in a patient during hemodialysis includes measuring serum potassium concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a potassium mobilization clearance and a pre-dialysis distribution volume of potassium for the patient. Serum potassium concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated potassium mobilization clearance and pre-dialysis distribution volume of potassium of the patient.
摘要:
Disclosed is novel means for producing a platelet solution replaced with an artificial preservation solution, which means has a platelet-activation-suppressing performance, high platelet recovering performance, and high blood-plasma-removing performance. The method for producing a platelet solution replaced with an artificial preservation solution of the present invention comprises: a filtering step of carrying out cross-flow filtration of a platelet solution under the conditions of Formula 1 described below at an inlet wall shear rate of 25 to 1500 s -1 using a separation membrane whose surface which contacts with the platelet solution has an average pore size of not less than 0.1 µm and less than 2.0 µm, thereby obtaining a concentrated platelet solution; and a mixing step of mixing the concentrated platelet solution with an artificial preservation solution to obtain the platelet solution replaced with an artificial preservation solution. A: Concentration of platelets contained in the platelet solution (platelets/mL; with the proviso that the range is 8.0×10 7 to 200×10 7 platelets/mL) B: Filtration flow rate per unit area (mL/hr/m 2 ) ³: Inlet wall shear rate (s -1 ) µ P : Viscosity of the platelet solution (Pa·s)
摘要:
A membrane separation device for use in blood processing procedures is disclosed. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.