SOLUTION CIRCUIT APPARATUS WITH BYPASS, AND BLOOD PURIFICATION SYSTEM COMPRISING THE SOLUTION CIRCUIT APPARATUS

    公开(公告)号:EP3103495B1

    公开(公告)日:2018-08-29

    申请号:EP15171387.2

    申请日:2015-06-10

    IPC分类号: A61M5/44 A61M1/34

    摘要: A solution circuit apparatus (30) for a blood purification system (50) comprising an extracorporeal blood circuit (40) and the solution circuit apparatus (30), comprises: a solution source (1); a warmer (3) having a temperature sensor (8); a bypass branch (26); a delivery branch (25) communicating with the extracorporeal blood circuit (40); a pump (2); a switching means (5); and a control unit (39) configured to set the solution circuit apparatus (30) into one of a solution delivery condition and a solution stop condition. In the solution delivery condition the switching means (5) interrupts the bypass branch (26), and the pump (2) delivers solution via the warmer (3) and through the delivery branch (25). In the solution stop condition the switching means (5) interrupts the delivery branch (25), and the pump (2) recirculates solution through the warmer (3) via the bypass branch (26). In the therapy stop condition the pump rate is dependent on the output of the temperature sensor (8).

    THERAPY PREDICTION AND OPTIMIZATION OF SERUM POTASSIUM FOR RENAL FAILURE BLOOD THERAPY, ESPECIALLY HOME HEMODIALYSIS
    8.
    发明公开
    THERAPY PREDICTION AND OPTIMIZATION OF SERUM POTASSIUM FOR RENAL FAILURE BLOOD THERAPY, ESPECIALLY HOME HEMODIALYSIS 审中-公开
    血钾对肾功能衰竭血液治疗尤其是家庭血液透析治疗的预测和优化

    公开(公告)号:EP3229159A1

    公开(公告)日:2017-10-11

    申请号:EP17173110.2

    申请日:2014-08-08

    IPC分类号: G06F19/00

    摘要: A method of predicting serum potassium concentrations in a patient during hemodialysis includes measuring serum potassium concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a potassium mobilization clearance and a pre-dialysis distribution volume of potassium for the patient. Serum potassium concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated potassium mobilization clearance and pre-dialysis distribution volume of potassium of the patient.

    摘要翻译: 在血液透析期间预测患者血清钾浓度的方法包括在血液透析治疗期间测量患者的血清钾浓度和通过在初始血液透析期间患者透析前和透析后体重之间的差异计算超滤率 治疗时间除以治疗期的总治疗时间并估计患者的钾移动清除率和钾透析前分布量。 然后可以在任何血液透析治疗期间的任何时间预测患者的血清钾浓度,其中估计的钾流动清除率和患者的钾透析前分布容积。

    METHOD FOR PREPARING PLATELET SOLUTION REPLACED WITH ARTIFICIAL PRESERVATION SOLUTION
    9.
    发明授权
    METHOD FOR PREPARING PLATELET SOLUTION REPLACED WITH ARTIFICIAL PRESERVATION SOLUTION 有权
    用人工保存溶液代替血小板溶液的方法

    公开(公告)号:EP2926820B1

    公开(公告)日:2017-08-30

    申请号:EP13859504.6

    申请日:2013-11-27

    摘要: Disclosed is novel means for producing a platelet solution replaced with an artificial preservation solution, which means has a platelet-activation-suppressing performance, high platelet recovering performance, and high blood-plasma-removing performance. The method for producing a platelet solution replaced with an artificial preservation solution of the present invention comprises: a filtering step of carrying out cross-flow filtration of a platelet solution under the conditions of Formula 1 described below at an inlet wall shear rate of 25 to 1500 s -1 using a separation membrane whose surface which contacts with the platelet solution has an average pore size of not less than 0.1 µm and less than 2.0 µm, thereby obtaining a concentrated platelet solution; and a mixing step of mixing the concentrated platelet solution with an artificial preservation solution to obtain the platelet solution replaced with an artificial preservation solution. A: Concentration of platelets contained in the platelet solution (platelets/mL; with the proviso that the range is 8.0×10 7 to 200×10 7 platelets/mL) B: Filtration flow rate per unit area (mL/hr/m 2 ) ³: Inlet wall shear rate (s -1 ) µ P : Viscosity of the platelet solution (Pa·s)

    摘要翻译: 本发明公开了用人造保存液替代血小板液的新方法,其具有血小板活化抑制性能,高血小板恢复性能和高血浆去除性能。 用本发明的人造保存液代替血小板液的制造方法包括:过滤工序,在25℃〜25℃的入口壁剪切速度下,在下述式1的条件下进行血小板溶液的错流过滤。 使用与血小板溶液接触的表面具有不小于0.1μm且小于2.0μm的平均孔径的分离膜,由此获得浓缩的血小板溶液; 以及混合步骤,将浓缩的血小板溶液与人造保存溶液混合以获得替换为人造保存溶液的血小板溶液。 A:血小板溶液中含有的血小板浓度(血小板/ mL,条件是8.0×10 7〜200×10 7血小板/ mL)B:单位面积的过滤流量(mL / hr / m 2 )³:进口壁面剪切速率(s -1)μP:血小板溶液粘度(Pa·s)

    MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS
    10.
    发明授权
    MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 有权
    膜分离装置,使用该装置的系统和方法以及数据管理系统和方法

    公开(公告)号:EP2683455B1

    公开(公告)日:2017-08-30

    申请号:EP12756950.7

    申请日:2012-03-09

    申请人: Fenwal, Inc.

    摘要: A membrane separation device for use in blood processing procedures is disclosed. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

    摘要翻译: 公开了一种用于血液处理程序的膜分离装置。 在一个实施例中,提供了一种旋转膜分离器,其中在旋转膜和壳体之间的间隙中产生至少两个区域或区域,使得两个区域之间的流体的混合受到相关的径向肋或脊的抑制 通过旋转膜减小旋转膜和壳体之间的间隙以限定两个流体区域,脊分离两个区域中的流体以最小化两者之间的混合。 公开了自动系统和方法,用于将先前收集的全血单位分离成选定的血液成分,例如浓缩的红细胞和血浆,用于直接从供体收集红细胞和血浆,并用于细胞洗涤。 还公开了数据管理系统和方法以及启动方法。