公开(公告)号：EP2475407A1

公开(公告)日：2012-07-18

申请号：EP10752502.4

申请日：2010-09-01

申请人： Fresenius Medical Care Holdings, Inc.

发明人： OFSTHUN, Norma, J. ,  SANDFORD, Harold, F. ,  STENNETT, Amanda, K. ,  TEO, Jiunn, Yeong ,  FORD, Cheryl ,  LIPPS, Benjamin, J.

IPC分类号： A61M1/16 ,  A61M1/28

CPC分类号： A61M1/1696 ,  A61M1/28 ,  A61M1/284 ,  A61M1/3482 ,  A61M1/3486

摘要： A dialysate regeneration system for removing contaminants from spent dialysate according to this invention includes a dialysate circulation flow path including a pump (130) that pumps spent dialysate through the dialysate circulation flow path, a first cartridge (140) adapted to remove contaminants from the spent dialysate and being connected to a first cleaning solution flow path including a first cleaning stage (240), a second cartridge (150) adapted to remove urea from the spent dialysate, the second cartridge including semi-permeable hollow fibers adapted for transport of urea across the walls of the semi-permeable hollow fibers and adapted to retain at least calcium, magnesium, and sodium ions in the spent dialysate, the second cartridge being connected to a second cleaning solution flow path including a second cleaning stage (340).

公开(公告)号：EP2475407B1

公开(公告)日：2016-06-08

申请号：EP10752502.4

申请日：2010-09-01

申请人： Fresenius Medical Care Holdings, Inc.

发明人： OFSTHUN, Norma, J. ,  SANDFORD, Harold, F. ,  STENNETT, Amanda, K. ,  TEO, Jiunn, Yeong ,  FORD, Cheryl ,  LIPPS, Benjamin, J.

IPC分类号： A61M1/16 ,  A61M1/28

CPC分类号： A61M1/1696 ,  A61M1/28 ,  A61M1/284 ,  A61M1/3482 ,  A61M1/3486

公开(公告)号：EP2334292B1

公开(公告)日：2019-05-08

申请号：EP09753247.7

申请日：2009-10-16

申请人： Fresenius Medical Care Holdings, Inc.

发明人： GOTCH, Frank, A. ,  LIPPS, Benjamin, J. ,  KOTANKO, Peter ,  LEVIN, Nathan, W. ,  STENNETT, Amanda, K. ,  OFSTHUN, Norma, J.

IPC分类号： A61K31/00 ,  A61K31/785 ,  A61K33/06 ,  A61K45/06 ,  A61P3/12 ,  A61P3/14 ,  A61P13/12 ,  A61P35/00 ,  A61P7/08 ,  G01N33/84

公开(公告)号：EP2483685B1

公开(公告)日：2018-09-26

申请号：EP10763950.2

申请日：2010-10-01

申请人： Fresenius Medical Care Holdings, Inc.

发明人： GOTCH, Frank, A. ,  STENNETT, Amanda, K. ,  OFSTHUN, Norma, J.

IPC分类号： G01N33/50 ,  A61K31/785 ,  A61P13/12

CPC分类号： G01N33/62 ,  A61K31/785 ,  G01N33/68 ,  G01N33/84 ,  G01N2800/347 ,  G06F19/00 ,  G06F19/3475 ,  Y10T436/11 ,  Y10T436/15 ,  Y10T436/166666

摘要： A method of identifying a patient who is non-compliant with prescribed diet and/or phosphate binder regimen calculates a phosphorus-protein ratio (PPR) by calculating the patient's protein intake, measuring the patient's serum phosphorus concentration, and estimating the amount of phosphorus removed by the patient's kidneys from measured residual urea clearance. The PPR is the ratio between the total amount of phosphorus removed from the patient and the patient's protein intake. The method enables identifying a patient that is non-compliant with prescribed diet and/or phosphate binder regimen if the PPR is outside of an acceptable range.

公开(公告)号：EP2483685A1

公开(公告)日：2012-08-08

申请号：EP10763950.2

申请日：2010-10-01

申请人： Fresenius Medical Care Holdings, Inc.

发明人： GOTCH, Frank, A. ,  STENNETT, Amanda, K. ,  OFSTHUN, Norma, J.

IPC分类号： G01N33/50 ,  A61K31/785 ,  A61P13/12

CPC分类号： G01N33/62 ,  A61K31/785 ,  G01N33/68 ,  G01N33/84 ,  G01N2800/347 ,  G06F19/00 ,  G06F19/3475 ,  Y10T436/11 ,  Y10T436/15 ,  Y10T436/166666

摘要： A method of identifying a patient who is non-compliant with prescribed diet and/or phosphate binder regimen calculates a phosphorus-protein ratio (PPR) by calculating the patient's protein intake, measuring the patient's serum phosphorus concentration, and estimating the amount of phosphorus removed by the patient's kidneys from measured residual urea clearance. The PPR is the ratio between the total amount of phosphorus removed from the patient and the patient's protein intake. The method enables identifying a patient that is non-compliant with prescribed diet and/or phosphate binder regimen if the PPR is outside of an acceptable range.

公开(公告)号：EP2334292A1

公开(公告)日：2011-06-22

申请号：EP09753247.7

申请日：2009-10-16

申请人： Fresenius Medical Care Holdings, Inc.

发明人： GOTCH, Frank, A. ,  LIPPS, Benjamin, J. ,  KOTANKO, Peter ,  LEVIN, Nathan, W. ,  STENNETT, Amanda, K. ,  OFSTHUN, Norma, J.

IPC分类号： A61K31/00 ,  A61K31/785 ,  A61K33/06 ,  A61K45/06 ,  A61P3/12 ,  A61P3/14 ,  A61P13/12 ,  A61P35/00 ,  G01N33/84

CPC分类号： A61K31/785 ,  A61K31/00 ,  A61K33/06 ,  A61K45/06 ,  G01N33/84 ,  A61K2300/00

摘要： The invention is directed to a method of determining a dosage of phosphorus binder for a patient undergoing dialysis treatment to achieve a pre-dialysis serum phosphorus concentration within a desired concentration range while achieving a desired net accumulation of calcium. The method includes determining the dosage of phosphorus binder that will achieve pre-dialysis serum phosphorus concentration of the patient that is within the desired concentration range while accounting for the change in the amount of phosphorus removed by the dialysis treatment when the pre-dialysis serum phosphorus concentration of the patient is within the desired concentration range, determining a dialysate calcium concentration that will result in the desired net accumulation of calcium over a complete dialysis cycle, and dialyzing the patient with a dialysate containing a calcium concentration based upon that determination.