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公开(公告)号：EP3094345B1
公开(公告)日：2018-03-14
申请号：EP15700478.9
申请日：2015-01-16
申请人： Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol , Fundació Institut Català de Nanociència i Nanotecnologia , Institució Catalana de Recerca i Estudis Avançats
发明人： MASPOCH COMAMALA, Daniel , CANO SARABIA, Antonia María , VIVES PI, Marta , PUJOL AUTONELL, Irma , VERDAGUER AUTONELL, Juan
CPC分类号： A61K9/127 , A61K39/0008 , A61K2039/577
摘要： The present invention provides a liposome encapsulating an autoantigen, wherein the liposome has a size comprised from 500 to 15000 nm and the liposome membrane comprises phosphatydilserine (PS) in an amount comprised from 10 to 40% by weight with respect to the total membrane liposomal composition. Pharmaceutical or veterinary compositions comprising a therapeutically effective amount of said liposome are also provided. Further, the invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use as a medicament, particularly for the treatment of autoimmune diseases. Finally the present invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use in the restoration of tolerance to self in a patient suffering from an autoimmune disease.
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公开(公告)号：EP3094345A1
公开(公告)日：2016-11-23
申请号：EP15700478.9
申请日：2015-01-16
申请人： Fundació Institut per a La Investìgació en Cíèncie de la Salut "Germans Trias I Pujol" (IGTP) , Fundació Institut Català de Nanociència i Nanotecnologia , Institució Catalana de Recerca i Estudis Avançats
发明人： MASPOCH COMAMALA, Daniel , CANO SARABIA, Antonia María , VIVES PI, Marta , PUJOL AUTONELL, Irma , VERDAGUER AUTONELL, Juan
CPC分类号： A61K9/127 , A61K39/0008 , A61K2039/577
摘要： The present invention provides a liposome encapsulating an autoantigen, wherein the liposome has a size comprised from 500 to 15000 nm and the liposome membrane comprises phosphatydilserine (PS) in an amount comprised from 10 to 40% by weight with respect to the total membrane liposomal composition. Pharmaceutical or veterinary compositions comprising a therapeutically effective amount of said liposome are also provided. Further, the invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use as a medicament, particularly for the treatment of autoimmune diseases. Finally the present invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use in the restoration of tolerance to self in a patient suffering from an autoimmune disease.
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公开(公告)号：EP3990002A1
公开(公告)日：2022-05-04
申请号：EP20734402.9
申请日：2020-06-26
申请人： Universitat de Lleida , Institut de Recerca Biomèdica de Lleida Fundació Dr Pifarré , Fundació Institut D'investigació En Ciències De La Salut Germans Trias i Pujol , Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca
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