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公开(公告)号：EP3094345B1
公开(公告)日：2018-03-14
申请号：EP15700478.9
申请日：2015-01-16
申请人： Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol , Fundació Institut Català de Nanociència i Nanotecnologia , Institució Catalana de Recerca i Estudis Avançats
发明人： MASPOCH COMAMALA, Daniel , CANO SARABIA, Antonia María , VIVES PI, Marta , PUJOL AUTONELL, Irma , VERDAGUER AUTONELL, Juan
CPC分类号： A61K9/127 , A61K39/0008 , A61K2039/577
摘要： The present invention provides a liposome encapsulating an autoantigen, wherein the liposome has a size comprised from 500 to 15000 nm and the liposome membrane comprises phosphatydilserine (PS) in an amount comprised from 10 to 40% by weight with respect to the total membrane liposomal composition. Pharmaceutical or veterinary compositions comprising a therapeutically effective amount of said liposome are also provided. Further, the invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use as a medicament, particularly for the treatment of autoimmune diseases. Finally the present invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use in the restoration of tolerance to self in a patient suffering from an autoimmune disease.
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公开(公告)号：EP3094345A1
公开(公告)日：2016-11-23
申请号：EP15700478.9
申请日：2015-01-16
申请人： Fundació Institut per a La Investìgació en Cíèncie de la Salut "Germans Trias I Pujol" (IGTP) , Fundació Institut Català de Nanociència i Nanotecnologia , Institució Catalana de Recerca i Estudis Avançats
发明人： MASPOCH COMAMALA, Daniel , CANO SARABIA, Antonia María , VIVES PI, Marta , PUJOL AUTONELL, Irma , VERDAGUER AUTONELL, Juan
CPC分类号： A61K9/127 , A61K39/0008 , A61K2039/577
摘要： The present invention provides a liposome encapsulating an autoantigen, wherein the liposome has a size comprised from 500 to 15000 nm and the liposome membrane comprises phosphatydilserine (PS) in an amount comprised from 10 to 40% by weight with respect to the total membrane liposomal composition. Pharmaceutical or veterinary compositions comprising a therapeutically effective amount of said liposome are also provided. Further, the invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use as a medicament, particularly for the treatment of autoimmune diseases. Finally the present invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use in the restoration of tolerance to self in a patient suffering from an autoimmune disease.
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公开(公告)号：EP3160446A1
公开(公告)日：2017-05-03
申请号：EP15705303.4
申请日：2015-02-18
申请人： Universitat Autònoma de Barcelona , Fundacio Privada Institut Catala de Nanociencia I Nanotecnologia (ICN2) , Institució Catalana De Recerca I Estudis Avançats (ICREA)
发明人： MASPOCH COMAMALA, Daniel , CANO SARABIA, Antonia María , LLAGOSTERA CASAS, Montserrat , CORTÉS GARMENDIA, María Pilar , CAMPOY SÁNCHEZ, Susana , COLOM COMAS, Joan
CPC分类号： A61K9/1271 , A23K40/30 , A23L3/3472 , A23P10/35 , A61K35/76 , A61K47/24 , C12N7/00 , C12N2795/10332
摘要： The present invention provides novel coated bacteriophages and formulations comprising the same, which are characterized by comprising lipidic coated bacteriophages useful in different industrial applications, such as, therapeutic and prophylactic agents in the field of human and veterinary industries, control of bacteria population in livestock in general, and as sanitizing and/or sterilization agents in animal and food production and processing industries. The lipid mixture forming the lipidic capsules, vesicles, envelopes or liposome like particles of the present invention comprises a mixture of four different lipidic components, namely, a first, a second, a third and a fourth lipidic component. Each of these different four lipid components may comprise at least one lipid substance selected from a specific closed list of lipid substances.
摘要翻译： 本发明提供了新的包被的噬菌体和包含它的制剂，其特征在于包含可用于不同工业应用的脂质包被的噬菌体，例如人和兽医工业领域的治疗剂和预防剂，控制家畜中的细菌数量 一般，以及作为动物和食品生产和加工工业中的消毒和/或消毒剂。 形成本发明的脂质胶囊，囊泡，包膜或脂质体样颗粒的脂质混合物包含四种不同脂质组分的混合物，即第一种，第二种，第三种和第四种脂质组分。 这些不同的四种脂质组分中的每一种可以包含至少一种选自脂质物质的特定封闭列表的脂质物质。
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4.发明授权METHOD FOR THE PREPARATION OF METAL ORGANIC FRAMEWORKS 有权VERFAHREN ZUR HERSTELLUNG金属分析器组织RAHMENWERKE
公开(公告)号：EP2764004B1
公开(公告)日：2015-12-30
申请号：EP12766986.9
申请日：2012-10-03
CPC分类号： B29B9/12 , B01J20/226 , B01J31/16 , B01J31/1691 , C07C51/412 , C07C51/418 , C07F1/005 , C07F3/003 , C07F15/025 , C07F19/00 , C07C57/145 , C07C65/05 , C07C63/307 , C07C63/331
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公开(公告)号：EP2764004A1
公开(公告)日：2014-08-13
申请号：EP12766986.9
申请日：2012-10-03
CPC分类号： B29B9/12 , B01J20/226 , B01J31/16 , B01J31/1691 , C07C51/412 , C07C51/418 , C07F1/005 , C07F3/003 , C07F15/025 , C07F19/00 , C07C57/145 , C07C65/05 , C07C63/307 , C07C63/331
摘要： A process for the preparation of a dry crystalline metal organic framework which comprises: a) spray drying at least one metal ion and at least one organic ligand which is at least bidentate into a spray dryer in the presence of a solvent, wherein the reaction of the at least one metal ion with the at least one organic ligand to yield the metal organic framework and the drying of the obtained metal organic framework take place simultaneously inside the spray dryer, and b) collecting the formed dry crystalline metal organic framework.
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