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1.发明公开
公开(公告)号：EP3981421A1
公开(公告)日：2022-04-13
申请号：EP20382883.5
申请日：2020-10-06
发明人： MAYÁN SANTOS, María Dolores , VARELA VÁZQUEZ, Adrián , GUITIÁN CAAMAÑO, Amanda , CARPINTERO FERNÁNDEZ, Paula , VARELA EIRÍN, Marta , FONSECA CAPDEVILA, Eduardo , QUINDÓS VARELA, María , CALLEJA CHUCLA, Teresa
摘要： The present invention refers to Cx43, preferably in combination with an inhibitor of a mitogen-activated protein kinase (MAPK) selected from the list consisting of: BRAF, RAS, MEK or ERK, for use in the treatment of cancer wherein the cancer is characterized by the activation of mitogen-activated protein kinase (MAPK) selected from the list consisting of: BRAF, RAS, MEK or ERK.
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公开(公告)号：EP4122485A1
公开(公告)日：2023-01-25
申请号：EP21382657.1
申请日：2021-07-20
发明人： MAYÁN SANTOS, María Dolores , CARPINTERO FERNÁNDEZ, Paula , GARCÍA YUSTE, Alejandro , ACEA NEBRIL, Benigno , FONSECA CAPDEVILA, Eduardo
IPC分类号： A61K38/17 , A61P35/00 , A61K31/495
摘要： The present invention to connexin 43 (Cx43) for use in the treatment of a type of cancer characterized by the presence of functional retinoblastoma gene (RB), or by the presence of functional RB and also by hyperactivity of CDK4 and CDK6, preferably in combination with a CDK4/6 inhibitor.
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3.发明公开
公开(公告)号：EP4225347A1
公开(公告)日：2023-08-16
申请号：EP21783547.9
申请日：2021-10-06
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公开(公告)号：EP4373514A1
公开(公告)日：2024-05-29
申请号：EP22751728.1
申请日：2022-07-20
发明人： MAYÁN SANTOS, María Dolores , CARPINTERO FERNÁNDEZ, Paula , GARCÍA YUSTE, Alejandro , ACEA NEBRIL, Benigno , FONSECA CAPDEVILA, Eduardo
IPC分类号： A61K38/17 , A61P35/00 , A61K31/495
CPC分类号： A61K38/1709 , A61P35/00 , A61K31/506 , A61K31/519 , A61K31/635 , A61K45/06
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公开(公告)号：EP3960748A1
公开(公告)日：2022-03-02
申请号：EP20796375.2
申请日：2020-04-27
申请人： Fundación Profesor Novoa Santos , Servizo Galego de Saúde (SERGAS) , Universidade Da Coruña , Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal
发明人： MAYÁN SANTOS, María Dolores , ACEA NEBRIL, Benigno , VARELA EIRÍN, Marta , RODRÍGUEZ CANDELA MATEOS, Marina , DÍAZ CARBALLA, Carlota Czestokowa , FONSECA CAPDEVILA, Eduardo , BARRIO CALVO, Luis Carlos , ESCUDERO LÓPEZ, Adela
IPC分类号： C07H1/08 , C07D231/40 , A61K8/30 , A61K31/7048 , A61Q19/00
摘要： The present invention relates to the use of a composition for the treatment and/or prevention of the side-effects of radiotherapy and/or chemotherapy, preferably as a protective post-treatment composition, that is, the effect is produced once the cells have been radiated (restores phenotype and gap junctions and reduces senescence). Accordingly, the composition comprises two chemical compounds that can protect and treat tissues that have been affected or are at risk of being affected by the side effects of chemotherapy and/or radiotherapy. The invention also relates to a kit comprising the composition of the invention for the treatment and/or prevention of the side-effects of radiotherapy and/or chemotherapy.
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