公开(公告)号：EP4373514A1

公开(公告)日：2024-05-29

申请号：EP22751728.1

申请日：2022-07-20

申请人： Fundación Profesor Novoa Santos ,  Servizo Galego De Saúde

发明人： MAYÁN SANTOS, María Dolores ,  CARPINTERO FERNÁNDEZ, Paula ,  GARCÍA YUSTE, Alejandro ,  ACEA NEBRIL, Benigno ,  FONSECA CAPDEVILA, Eduardo

IPC分类号： A61K38/17 ,  A61P35/00 ,  A61K31/495

CPC分类号： A61K38/1709 ,  A61P35/00 ,  A61K31/506 ,  A61K31/519 ,  A61K31/635 ,  A61K45/06

公开(公告)号：EP3960748A1

公开(公告)日：2022-03-02

申请号：EP20796375.2

申请日：2020-04-27

申请人： Fundación Profesor Novoa Santos ,  Servizo Galego de Saúde (SERGAS) ,  Universidade Da Coruña ,  Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal

发明人： MAYÁN SANTOS, María Dolores ,  ACEA NEBRIL, Benigno ,  VARELA EIRÍN, Marta ,  RODRÍGUEZ CANDELA MATEOS, Marina ,  DÍAZ CARBALLA, Carlota Czestokowa ,  FONSECA CAPDEVILA, Eduardo ,  BARRIO CALVO, Luis Carlos ,  ESCUDERO LÓPEZ, Adela

IPC分类号： C07H1/08 ,  C07D231/40 ,  A61K8/30 ,  A61K31/7048 ,  A61Q19/00

摘要： The present invention relates to the use of a composition for the treatment and/or prevention of the side-effects of radiotherapy and/or chemotherapy, preferably as a protective post-treatment composition, that is, the effect is produced once the cells have been radiated (restores phenotype and gap junctions and reduces senescence). Accordingly, the composition comprises two chemical compounds that can protect and treat tissues that have been affected or are at risk of being affected by the side effects of chemotherapy and/or radiotherapy. The invention also relates to a kit comprising the composition of the invention for the treatment and/or prevention of the side-effects of radiotherapy and/or chemotherapy.

公开(公告)号：EP3908841A1

公开(公告)日：2021-11-17

申请号：EP20700163.7

申请日：2020-01-10

申请人： Fundación Biomédica Galicia Sur (FBGS) ,  Servizo Galego de Saúde (SERGAS) ,  Universidad de Vigo

发明人： SPUCH CALVAR, Carlos ,  RIVERA BALTANÁS, Tania ,  OLIVARES DÍAZ, Jose Manuel ,  CORREA DUARTE, Miguel Ángel ,  PEREZ LORENZO, Moisés ,  SALGUEIRIÑO MACEIRA, Verónica ,  SOUSA CASTILLO, Ana ,  BLANCO FORMOSO, María

IPC分类号： G01N33/68

公开(公告)号：EP3349007A1

公开(公告)日：2018-07-18

申请号：EP16843721.8

申请日：2016-09-09

申请人： Universidade de Santiago de Compostela ,  Servizo Galego De Saúde (Sergas) ,  FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA

发明人： ALONSO SAMPEDRO, Manuela ,  ÁLVAREZ GONZÁLEZ, Víctor ,  COLÓN MEJERAS, Cristóbal ,  GARCÍA GONZÁLEZ, Miguel A. ,  LAMAS GONZÁLEZ, Olaya

IPC分类号： G01N33/53

CPC分类号： G01N33/6839 ,  G01N33/5091 ,  G01N33/53 ,  G01N33/585 ,  G01N2400/40 ,  G01N2800/04 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention is comprised in the field of glycobiology. In particular, it relates to a method for separating, in biological samples, the fraction bound to or associated with sulfated glycosaminoglycans (GAGs), and the applications thereof in biomedicine, such as for identifying the profile of glycoproteins or the profile of lipids bound to or associated with sulfated GAGs, detecting an alteration in the pattern of glycosylation by sulfated GAGs, identifying biomarkers for the diagnosis, for the prognosis, for monitoring the progression of a disease or of the effect of a therapy, or for identifying compounds suitable for the treatment of a disease. The invention also relates to methods for diagnosing mucopolysaccharidosis and for diagnosing and determining the prognosis of a kidney disease.

公开(公告)号：EP3279337A1

公开(公告)日：2018-02-07

申请号：EP16382389.1

申请日：2016-08-04

申请人： Servizo Galego de Saúde (SERGAS) ,  Fundación Profesor Novoa Santos

发明人： TOMÁS CARMONA, María del Mar ,  BOU ARÉVALO, Germán ,  FERNÁNDEZ GONZÁLEZ, Ana ,  MOURE GONZÁLEZ, Raquel

IPC分类号： C12Q1/68 ,  C12Q1/70

CPC分类号： C12Q1/6851 ,  C12Q1/689 ,  C12Q1/6893 ,  C12Q1/705 ,  C12Q2600/16 ,  Y02A50/58 ,  C12Q2525/113 ,  C12Q2525/204 ,  C12Q2537/143 ,  C12Q2561/101 ,  C12Q2531/113

摘要： The present invention provides a new PCR technique-based method for simultaneously detecting several pathogens present in one and the same sample. The present invention therefore relates to a method for the detection, quantification and identification of pathogens of two or more different strains or species of microorganisms in one and the same biological sample isolated from a subject through polymerase chain reaction (PCR), preferably performed in a quantitative manner in real time, which comprises detecting, identifying and quantifying the presence or absence of said microorganisms in said biological sample through the determination and quantification of the presence or absence of amplicons from the polymerase chain reaction (PCR), preferably performed in a quantitative manner in real time.

摘要翻译： 本发明提供了用于同时检测同一样品中存在的多种病原体的基于PCR技术的新方法。 本发明因此涉及一种用于通过聚合酶链式反应（PCR）从受试者分离的同一生物样品中检测，定量和鉴定两种或更多种不同菌株或微生物物种的病原体的方法，所述生物样品优选在 其包括通过确定和定量来自聚合酶链式反应（PCR）的扩增子的存在或不存在来检测，鉴定和定量所述生物样品中所述微生物的存在或不存在，所述扩增子优选地以定量方式进行 实时的方式。

公开(公告)号：EP2792753A1

公开(公告)日：2014-10-22

申请号：EP12858582.5

申请日：2012-12-14

申请人： Fundación Pública Andaluza Progreso Y Salud ,  Servicio Andaluz de Salud ,  Agencia Pública Empresarial Sanitaria Hospital de Poniente ,  Servizo Galego De Saúde (Sergas) ,  Fundación para la Investigación del Hospital Universitario La Fe

发明人： LÓPEZ ESCAMEZ, Jose Antonio ,  LÓPEZ NEVOT, Miguel Ángel ,  GAZQUEZ PÉREZ, Irene ,  MORENO CASARES, Antonia María ,  LÓPEZ NEVOT, Alicia ,  REQUENA NAVARRO, María Teresa ,  ARAN GONZÁLEZ, Ismael ,  SOTO VARELA, Andrés ,  SANTOS PÉREZ, Sofía ,  PÉREZ GARRIGUES, Herminio

IPC分类号： C12Q1/68 ,  C12N15/12

CPC分类号： C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The invention relates to: a method for obtaining data that can be used to determine an individual's risk of suffering from severe neurosensory hypoacusis, preferably in Ménière's disease, primers that can be used in the determination, and a kit comprising same.

摘要翻译： 本发明涉及：用于获得可用于确定个体患有严重神经感觉性胸膜炎，优选梅内尔病的风险的方法，可用于测定的引物，以及包含该试剂盒的试剂盒。

公开(公告)号：EP4343001A1

公开(公告)日：2024-03-27

申请号：EP22382873.2

申请日：2022-09-22

申请人： Universidade de Santiago de Compostela ,  Servizo Galego De Saúde

发明人： José Manuel, LEIRO VIDAL ,  Jesús, LAMAS FERNÁNDEZ ,  Rosa Ana, SUEIRO BENAVIDES ,  Iria, BASTÓN REY ,  Manuel, BARREIRO DE ACOSTA ,  Juan Enrique, DOMÍNGUEZ MUÑOZ

IPC分类号： C12Q1/6883 ,  C12Q1/689

摘要： The invention relates to a method for the diagnosis of ulcerative colitis in a subject by detecting a nucleic acid target region and to oligonucleotides, oligonucleotide probes and kits to be used in this method.

公开(公告)号：EP3923937A1

公开(公告)日：2021-12-22

申请号：EP20704023.9

申请日：2020-02-10

申请人： Servizo Galego De Saúde ,  Fundación Instituto de Investigación Sanitaria de Santiago de Compostela

发明人： GÓMEZ BAHAMONDE, Rodolfo ,  FRANCO TREPAT, Eloi ,  ALONSO PÉREZ, Ana ,  GUILLÁN FRESCO, María ,  JORGE MORA, Alberto

IPC分类号： A61K31/4439 ,  A61K31/405 ,  A61K45/06 ,  A61P19/08 ,  A61K31/573

公开(公告)号：EP3454842B1

公开(公告)日：2020-07-08

申请号：EP17726564.2

申请日：2017-05-12

申请人： Servizo Galego De Saúde (Sergas) ,  Universidade de Santiago de Compostela

发明人： PEGO REIGOSA, José María ,  CORDERO SANTAMARÍA, Óscar ,  VARELA CALVIÑO, Rubén

IPC分类号： A61K31/00 ,  G01N33/564

公开(公告)号：EP3608675A1

公开(公告)日：2020-02-12

申请号：EP19200400.0

申请日：2016-02-16

申请人： Universidade de Santiago de Compostela ,  Servizo Galego de Saúde (SERGAS)

发明人： LEMA GESTO, María Isabel ,  CASTILLO SÁNCHEZ, José Antonio ,  SOBRINO MOREIRAS, Tomás ,  CAMPOS PEREZ, Francisco

IPC分类号： G01N33/68

摘要： The invention relates to the field of the diagnosis and prognosis methods of molecular pathologies. In particular, the invention relates to methods for determining the diagnosis of an ectatic disease of the cornea in a subject, for determining the risk of developing an ectatic disease of the cornea in a subject, for determining the clinical outcome of a subject suffering from an ectatic disease of the cornea and for selecting a subject to be treated with a therapy for an ectatic disease of the cornea based on the determination of the expression levels of TLR2 and/or TLR4 markers. The invention also relates to the use of the TLR2 and/or TLR4 as diagnosis and prognosis markers for an ectatic disease of the cornea.