公开(公告)号：EP3765093A1

公开(公告)日：2021-01-20

申请号：EP19767510.1

申请日：2019-03-14

申请人： Fundamental Solutions Corporation

发明人： TANG, Yuanyuan ,  KITTLE, Joseph, D. ,  LWANDE, Joel, S. ,  LIANG, Shengwen

IPC分类号： A61K48/00 ,  C07K14/705 ,  C07K14/725 ,  C07K14/73

公开(公告)号：EP3404410A3

公开(公告)日：2019-01-30

申请号：EP18180720.7

申请日：2016-03-31

申请人： Fundamental Solutions Corporation

发明人： ZENG, Lingchun ,  ZUPANCIC, Thomas, J. ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

IPC分类号： G01N33/554

摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.

公开(公告)号：EP3559278A1

公开(公告)日：2019-10-30

申请号：EP17838104.2

申请日：2017-12-21

申请人： Fundamental Solutions Corporation

发明人： ZUPANCIC, Thomas, J. ,  KITTLE, Joseph, D. ,  ZENG, Lingchun ,  VEDAMOORTHY, Srikanth ,  BRODY, Richard, S. ,  WILLIAMS, Marvin, R.

IPC分类号： C12Q1/6897 ,  G01N33/50 ,  G01N33/536 ,  G01N33/554 ,  G01N33/569 ,  G01N33/58

公开(公告)号：EP3404412A3

公开(公告)日：2019-02-13

申请号：EP18180727.2

申请日：2016-03-31

申请人： Fundamental Solutions Corporation

发明人： ZUPANCIC, Thomas, J. ,  ZENG, Lingchun ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

IPC分类号： G01N33/554

摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.

公开(公告)号：EP3404412A2

公开(公告)日：2018-11-21

申请号：EP18180727.2

申请日：2016-03-31

申请人： Fundamental Solutions Corporation

发明人： ZUPANCIC, Thomas, J. ,  ZENG, Lingchun ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

IPC分类号： G01N33/554

CPC分类号： C07K14/70535 ,  C07K14/7051 ,  C07K2319/00 ,  C07K2319/22 ,  G01N33/554 ,  G01N33/56911 ,  G01N33/56983

摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.

公开(公告)号：EP3404410A2

公开(公告)日：2018-11-21

申请号：EP18180720.7

申请日：2016-03-31

申请人： Fundamental Solutions Corporation

发明人： ZENG, Lingchun ,  ZUPANCIC, Thomas, J. ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

IPC分类号： G01N33/554

CPC分类号： C07K14/70535 ,  C07K14/7051 ,  C07K2319/00 ,  C07K2319/22 ,  G01N33/554 ,  G01N33/56911 ,  G01N33/56983

摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.

公开(公告)号：EP3470527A1

公开(公告)日：2019-04-17

申请号：EP18209257.7

申请日：2016-03-31

申请人： Fundamental Solutions Corporation

发明人： ZUPANCIC, Thomas, J. ,  ZENG, Lingchun ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

IPC分类号： C12Q1/04 ,  G01N33/554 ,  G01N33/569

摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.

公开(公告)号：EP3404411A3

公开(公告)日：2019-02-13

申请号：EP18180724.9

申请日：2016-03-31

申请人： Fundamental Solutions Corporation

发明人： ZENG, Lingchun ,  ZUPANCIC, Thomas, J. ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

IPC分类号： G01N33/554

摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.

公开(公告)号：EP3404411A2

公开(公告)日：2018-11-21

申请号：EP18180724.9

申请日：2016-03-31

申请人： Fundamental Solutions Corporation

发明人： ZENG, Lingchun ,  ZUPANCIC, Thomas, J. ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

IPC分类号： G01N33/554

CPC分类号： C07K14/70535 ,  C07K14/7051 ,  C07K2319/00 ,  C07K2319/22 ,  G01N33/554 ,  G01N33/56911 ,  G01N33/56983

摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.

公开(公告)号：EP3277831A2

公开(公告)日：2018-02-07

申请号：EP16774179.2

申请日：2016-03-31

申请人： Fundamental Solutions Corporation

发明人： ZUPANCIC, Thomas, J. ,  ZENG, Lingchun ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

IPC分类号： C12Q1/04 ,  G01N33/554 ,  G01N33/569

CPC分类号： C07K14/70535 ,  C07K14/7051 ,  C07K2319/00 ,  C07K2319/22 ,  G01N33/554 ,  G01N33/56911 ,  G01N33/56983

摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.