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1.发明公开
公开(公告)号：EP0912901A1
公开(公告)日：1999-05-06
申请号：EP97924591.0
申请日：1997-05-12
申请人： G.D. SEARLE & CO.
发明人： CARRON, Christopher, P. , FEIGEN, Larry, P. , HAAS, Neal, F. , MEYER, Debra, M. , PAGE, Jimmy, D. , PEGG, Jodi, Ann
CPC分类号： C07K16/44 , G01N33/86 , G01N33/94 , Y10S435/808 , Y10S435/975
摘要： A method for determining the amount of an antiplatelet compound in a subject being treated with the compound which comprises calculating the ACT number of the subject's blood containing a reagent which immunoreacts with the antiplatelet compound and comparing the figure to a standardized concentration figure. In subjects concurrently being treated with heparin and antiplatelet compounds, the method can be practiced without additional heparin added to the blood sample. The invention also provides reagents which immunoreact with antiplatelet compounds and kits comprising immunoreactive reagents.
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公开(公告)号：EP0973550B1
公开(公告)日：2002-10-09
申请号：EP98915334.1
申请日：1998-04-09
申请人： G.D. SEARLE & CO.
IPC分类号： A61K39/395
CPC分类号： C07K16/2848 , A61K38/00 , A61K51/1027 , A61K2039/505
摘要： Monoclonal antibodies that recognize the alphav beta3 integrin receptor complex, but do not significantly bind to alphaIIbbetaIIIa, inhibit alphavbeta3 integrin-mediated diseases.
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3.发明授权
公开(公告)号：EP0912901B1
公开(公告)日：2001-11-07
申请号：EP97924591.7
申请日：1997-05-12
申请人： G.D. SEARLE & CO.
发明人： CARRON, Christopher, P. , FEIGEN, Larry, P. , HAAS, Neal, F. , MEYER, Debra, M. , PAGE, Jimmy, D. , PEGG, Jodi, Ann
CPC分类号： C07K16/44 , G01N33/86 , G01N33/94 , Y10S435/808 , Y10S435/975
摘要： A method for determining the amount of an antiplatelet compound in a subject being treated with the compound which comprises calculating the ACT number of the subject's blood containing a reagent which immunoreacts with the antiplatelet compound and comparing the figure to a standardized concentration figure. In subjects concurrently being treated with heparin and antiplatelet compounds, the method can be practiced without additional heparin added to the blood sample. The invention also provides reagents which immunoreact with antiplatelet compounds and kits comprising immunoreactive reagents.
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公开(公告)号：EP0973550A1
公开(公告)日：2000-01-26
申请号：EP98915334.1
申请日：1998-04-09
申请人： G.D. SEARLE & CO.
IPC分类号： A61K39/395
CPC分类号： C07K16/2848 , A61K38/00 , A61K51/1027 , A61K2039/505
摘要： Monoclonal antibodies that recognize the alphav beta3 integrin receptor complex, but do not significantly bind to alphaIIbbetaIIIa, inhibit alphavbeta3 integrin-mediated diseases.
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