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公开(公告)号：EP0828721A1
公开(公告)日：1998-03-18
申请号：EP96914762.0
申请日：1996-05-23
申请人： G.D. SEARLE & CO.
发明人： ABOOD, Norman , FLYNN, Daniel, L. , BECKER, Daniel, P. , BAX, Brian, M. , LI, Hui , NOSAL, Roger, A. , SCHRETZMAN, Lori, A. , VILLAMIL, Clara, I. , BENNETT, Michael, J. , BEDELL, John, L. , WILLIAMS, Kenneth
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
摘要： A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by formula (I) wherein R - R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
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公开(公告)号：EP0888322B1
公开(公告)日：2002-09-18
申请号：EP97914954.9
申请日：1997-03-19
申请人： G.D. SEARLE & CO.
IPC分类号： C07D333/70 , A61K31/165 , A61K31/34 , A61K31/38 , C07D307/85 , C07D307/68 , C07D241/24 , C07D213/81 , C07D209/42
CPC分类号： C07D213/81 , C07C233/33 , C07C235/24 , C07C235/64 , C07D209/42 , C07D241/24 , C07D307/68
摘要： A class of compounds is described which can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula (II) wherein each of R?1, R2, and R3¿ is independently selected from hydrido, halo, and nitro; wherein R8 is selected from haloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted arylalkoxy and optionally substituted aryloxyalkyl; wherein Y is selected from fluoroalkyl, and (A); and wherein (R9) is alkylamino; or a pharmaceutically-acceptable salt or tautomer thereof.
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公开(公告)号：EP0828721B1
公开(公告)日：2001-11-14
申请号：EP96914762.8
申请日：1996-05-23
申请人： G.D. SEARLE & CO.
发明人： ABOOD, Norman , FLYNN, Daniel, L. , BECKER, Daniel, P. , BAX, Brian, M. , LI, Hui , NOSAL, Roger, A. , SCHRETZMAN, Lori, A. , VILLAMIL, Clara, I. , BENNETT, Michael, J. , BEDELL, John, L. , WILLIAMS, Kenneth
IPC分类号： C07D265/24 , C07D413/12 , A61K31/535
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
摘要： A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by formula (I) wherein R - R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
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4.发明授权1-AMIDINOPHENYL-PYRROLIDONES/ PIPERIDINONES AS PLATELET AGGREGATION INHIBITORS 失效1-AMDINOPHENYL吡咯烷酮/哌啶酮ALS血小板聚集抑制剂
公开(公告)号：EP0691953B1
公开(公告)日：2000-08-02
申请号：EP94913308.6
申请日：1994-03-30
申请人： G.D. SEARLE & CO.
发明人： ABOOD, Norman, Anthony , FLYNN, Daniel, Lee , GARLAND, Robert, Bruce , SCHRETZMAN, Lori, Ann , WILLIAMS, Kenneth , ZABLOCKI, Jeffery, Alan , HOCKERMAN, Susan, Landis
IPC分类号： C07D207/26 , C07D205/08 , C07D211/76 , C07D405/12 , C07D409/12 , A61K31/40 , A61K31/445
CPC分类号： C07D207/26 , C07D205/085 , C07D207/273 , C07D211/76 , C07D405/12 , C07D409/12 , C07F7/0812
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公开(公告)号：EP0888322A2
公开(公告)日：1999-01-07
申请号：EP97914954.0
申请日：1997-03-19
申请人： G.D. SEARLE & CO.
IPC分类号： C07D333 , A61K31 , A61P31 , C07C233 , C07C235 , C07C271 , C07D209 , C07D213 , C07D241 , C07D307
CPC分类号： C07D213/81 , C07C233/33 , C07C235/24 , C07C235/64 , C07D209/42 , C07D241/24 , C07D307/68
摘要： A class of compounds is described which can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula (II) wherein each of R?1, R2, and R3¿ is independently selected from hydrido, halo, and nitro; wherein R8 is selected from haloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted arylalkoxy and optionally substituted aryloxyalkyl; wherein Y is selected from fluoroalkyl, and (A); and wherein (R9) is alkylamino; or a pharmaceutically-acceptable salt or tautomer thereof.
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6.发明公开1-AMIDINOPHENYL-PYRROLIDONES PIPERIDINONES AZETINONES AS PLATELET AGGREGATION INHIBITORS 失效1-脒基苯基吡咯烷酮哌啶酮氮酮作为血小板聚集抑制剂
公开(公告)号：EP0691953A1
公开(公告)日：1996-01-17
申请号：EP94913308.0
申请日：1994-03-30
申请人： G.D. SEARLE & CO.
发明人： ABOOD, Norman, Anthony , FLYNN, Daniel, Lee , GARLAND, Robert, Bruce , SCHRETZMAN, Lori, Ann , WILLIAMS, Kenneth , ZABLOCKI, Jeffery, Alan , HOCKERMAN, Susan, Landis
IPC分类号： C07D227 , A61K31 , A61P7 , C07C255 , C07C271 , C07D205 , C07D207 , C07D211 , C07D405 , C07D409 , C07F7
CPC分类号： C07D207/26 , C07D205/085 , C07D207/273 , C07D211/76 , C07D405/12 , C07D409/12 , C07F7/0812
摘要： This invention relates to compounds having formula (I) or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions of such phenylamidines derivatives, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
摘要翻译： 本发明涉及用于抑制血小板聚集的具有式（I）的化合物或其药学上可接受的盐，涉及此类苯基脒衍生物的药物组合物，并且涉及通过施用这些化合物和组合物来抑制哺乳动物中血小板聚集的方法 。
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