公开(公告)号：EP1948693B1

公开(公告)日：2013-03-20

申请号：EP06818817.6

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  USENER, Dirk ,  FRITZ, Stefan ,  UHEREK, Christoph ,  BRANDENBURG, Gunda ,  GEPPERT, Harald-Gerhard ,  SCHRÖDER, Anja Kristina ,  THIEL, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48 ,  A61K51/10

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

公开(公告)号：EP1759013A2

公开(公告)日：2007-03-07

申请号：EP05747772.1

申请日：2005-05-11

申请人： Ganymed Pharmaceuticals AG

发明人： TÜRECI, Özlem ,  SAHIN, Ugur ,  SCHNEIDER, Sandra ,  HELFTENBEIN, Gerd ,  SCHLÜTER, Volker ,  USENER, Dirk ,  THIEL, Philippe

IPC分类号： C12Q1/68

CPC分类号： A61K39/39558 ,  A61K39/395 ,  A61K45/06 ,  C07K14/4748 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/53

摘要： The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

摘要翻译： 本发明涉及鉴定作为肿瘤相关表达的结果的基因产物和编码它的核酸。 本发明还涉及其中这些基因产物是异常肿瘤相关表达的结果的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码其的核酸。

公开(公告)号：EP1759013B1

公开(公告)日：2010-05-19

申请号：EP05747772.1

申请日：2005-05-11

申请人： Ganymed Pharmaceuticals AG

发明人： TÜRECI, Özlem ,  SAHIN, Ugur ,  SCHNEIDER, Sandra ,  HELFTENBEIN, Gerd ,  SCHLÜTER, Volker ,  USENER, Dirk ,  THIEL, Philippe ,  KOSLOWSKI, Michael

IPC分类号： C12Q1/68

CPC分类号： A61K39/39558 ,  A61K39/395 ,  A61K45/06 ,  C07K14/4748 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/53

摘要： The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

公开(公告)号：EP1948693A1

公开(公告)日：2008-07-30

申请号：EP06818817.6

申请日：2006-11-24

申请人： Ganymed Pharmaceuticals AG ,  Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  USENER, Dirk ,  FRITZ, Stefan ,  UHEREK, Cristoph ,  BRANDENBURG, Gunda ,  GEPPERT, Harald-Gerhard ,  SCHRÖDER, Anja Kristina ,  THIEL, Philippe

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N5/12 ,  A61K47/48

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

公开(公告)号：EP3382036A1

公开(公告)日：2018-10-03

申请号：EP18157525.9

申请日：2005-05-11

申请人： GANYMED Pharmaceuticals AG

发明人： TÜRECI, Özlem ,  SAHIN, Ugur ,  SCHNEIDER, Sandra ,  HELFTENBEIN, Gerd ,  SCHLÜTER, Volker ,  USENER, Dirk ,  THIEL, Philippe ,  KOSLOWSKI, Michael

IPC分类号： C12Q1/68

CPC分类号： A61K39/39558 ,  A61K39/395 ,  A61K45/06 ,  C07K14/4748 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/53

摘要： Erfindungsgemäß wurden Tumor-assoziiert exprimierte Genprodukte und die dafür kodierenden Nukleinsäuren identifiziert. Die vorliegende Erfindung betrifft die Therapie und Diagnose von Erkrankungen, bei denen diese Tumor-assoziiert exprimierten Genprodukte aberrant exprimiert werden. Des weiteren betrifft die Erfindung Proteine, Polypeptide und Peptide, die Tumor-assoziiert exprimiert werden und die dafür kodierenden Nukleinsäuren.