公开(公告)号：EP2621545A1

公开(公告)日：2013-08-07

申请号：EP11761385.1

申请日：2011-09-27

申请人： GE Healthcare Limited

发明人： INDREVOLL, Bard ,  HISCOCK, Duncan ,  ARBO, Bente, Elizabeth ,  BHALLA, Rajiv ,  GLASER, Matthias, Eberhard ,  MCROBBIE, Graeme, Walter

IPC分类号： A61K51/08 ,  A61K103/10

CPC分类号： A61K51/088

摘要： The present invention relates to radiopharmaceutical imaging
in vivo of apoptosis. The invention provides imaging agents which target apoptotic cells
via selective binding to the aminophospholipid phosphatidylethanolamine (PE), which is exposed on the surface of apoptotic cells. The radiopharmaceuticals comprise radiometal complexes of chelator conjugates of PE-binding peptides. Also provided are pharmaceutical compositions, kits and methods of
in vivo imaging.

公开(公告)号：EP2646061A1

公开(公告)日：2013-10-09

申请号：EP11793397.8

申请日：2011-12-01

申请人： GE Healthcare Limited

发明人： HISCOCK, Duncan ,  ARBO, Bente, Elizabeth ,  MCROBBIE, Graeme, Walter ,  INDREVOLL, Bard ,  BHALLA, Rajiv

IPC分类号： A61K51/08 ,  A61K51/04

CPC分类号： A61K51/088 ,  A61K51/0474

摘要： The present invention relates to radiopharmaceutical imaging
in vivo of apoptosis and other forms of cell death. The invention provides PET imaging agents which target apoptotic cells
via selective binding to the aminophospholipid phosphatidylethanolamine (PE), which is exposed on the surface of apoptotic cells. Also provided are pharmaceutical compositions, kits and methods of
in vivo imaging.