公开(公告)号：EP2654804A1

公开(公告)日：2013-10-30

申请号：EP11804897.4

申请日：2011-12-19

申请人： GE Healthcare Limited

发明人： HISCOCK, Duncan ,  INDREVOLL, Bard ,  IVESON, Peter ,  GLASER, Matthias, Eberhard ,  BHALLA, Rajiv ,  WILSON, Anthony

IPC分类号： A61K51/08 ,  A61K101/02 ,  C07K14/31

CPC分类号： A61K51/088 ,  C07B59/008 ,  C07K14/31 ,  C07K14/71 ,  C07K16/32

摘要： Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

摘要翻译： 包含与放射核子和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。

公开(公告)号：EP2621545A1

公开(公告)日：2013-08-07

申请号：EP11761385.1

申请日：2011-09-27

申请人： GE Healthcare Limited

发明人： INDREVOLL, Bard ,  HISCOCK, Duncan ,  ARBO, Bente, Elizabeth ,  BHALLA, Rajiv ,  GLASER, Matthias, Eberhard ,  MCROBBIE, Graeme, Walter

IPC分类号： A61K51/08 ,  A61K103/10

CPC分类号： A61K51/088

摘要： The present invention relates to radiopharmaceutical imaging
in vivo of apoptosis. The invention provides imaging agents which target apoptotic cells
via selective binding to the aminophospholipid phosphatidylethanolamine (PE), which is exposed on the surface of apoptotic cells. The radiopharmaceuticals comprise radiometal complexes of chelator conjugates of PE-binding peptides. Also provided are pharmaceutical compositions, kits and methods of
in vivo imaging.