专利检索 ap:("GENAERA CORPORATION") AND inv:"WILLIAMS, Jon" 第 1 页

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发明授权
AMINOSTEROL COMPOUNDS USEFUL AS INHIBITORS OF THE SODIUM/PROTON EXCHANGER (NHE), PHARMACEUTICAL METHODS AND COMPOSITIONS EMPLOYING SUCH INHIBITORS, AND PROCESSES FOR EVALUATING THE NHE-INHIBITORY EFFICACY OF COMPOUNDS 失效
标题翻译： AMINOSTERINVERBINDUNGEN它们的钠/质子泵抑制剂，药学方法和筹备工作

公开(公告)号：EP0832094B1

公开(公告)日：2004-02-11

申请号：EP96922490.6

申请日：1996-06-07

申请人： GENAERA CORPORATION

发明人： ZASLOFF, Michael , SHINNAR, Ann , KINNEY, William A. , WILLIAMS, Jon , RAO, Meena N. , ANDERSON, Mark , MCLANE, Michael , JONES, Steven

IPC分类号： C07J41/00 , A61K31/575 , G01N33/48

CPC分类号： G01N33/5008 , C07J41/0005 , G01N33/5011 , G01N33/5044 , G01N33/505 , G01N33/5058 , G01N33/5061 , G01N33/5088 , G01N2500/00

摘要： Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.