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公开(公告)号：EP0763114B1
公开(公告)日：2001-12-05
申请号：EP95922085.6
申请日：1995-05-19
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222
摘要： Polypeptide antigens are disclosed which are immunoreactive with sera from individuals having a non-A, non-B, non-C, non-D, non-E Hepatitis, herein designated Hepatitis G virus (HGV). Corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic polypeptides are taught. The antigens are useful in diagnostic methods for detecting the presence of HGV in test subjects. The antigens are also useful in vaccine and antibody preparations. In addition, the entire coding sequences of two HGV isolates are disclosed. Methods are presented for nucleic acid-based detection of HGV in samples and also methods for the isolation of further genomic sequences corresponding to HGV.
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公开(公告)号：EP0763114A2
公开(公告)日：1997-03-19
申请号：EP95922085.0
申请日：1995-05-19
IPC分类号： A61K , C07K , C12N , C12Q , G01N , G01N33 , A61K39 , C07K14 , C07K16 , C12N7 , C12N15 , C12P21 , C12Q1 , A61K38
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222
摘要： Polypeptide antigens are disclosed which are immunoreactive with sera from individuals having a non-A, non-B, non-C, non-D, non-E Hepatitis, herein designated Hepatitis G virus (HGV). Corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic polypeptides are taught. The antigens are useful in diagnostic methods for detecting the presence of HGV in test subjects. The antigens are also useful in vaccine and antibody preparations. In addition, the entire coding sequences of two HGV isolates are disclosed. Methods are presented for nucleic acid-based detection of HGV in samples and also methods for the isolation of further genomic sequences corresponding to HGV.
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