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公开(公告)号：EP1641822B1
公开(公告)日：2013-05-15
申请号：EP04754234.5
申请日：2004-06-02
申请人： Genentech, Inc.
发明人： ARNOTT, David , GURNEY, Austin , HASS, Philip , LEE, James , WU, Yan
CPC分类号： C07K16/244 , A61K38/00 , C07K14/54 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/6869 , Y02A50/463 , Y02A50/473
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterolgous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及一种新型天然存在的人类细胞因子，其由本文称为白细胞介素17A / F（IL-17A / F）的白细胞介素-17和白细胞介素-17F的异源二聚体组成。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的特异性抗体以及与本发明的多肽结合的方法 本发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：EP3594228A1
公开(公告)日：2020-01-15
申请号：EP19175735.0
申请日：2004-06-02
申请人： GENENTECH, INC.
发明人： WU, Yan , LEE, James , HASS, Phillip , GURNEY, Austin , ARNOTT, David
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterolgous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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3.发明公开
公开(公告)号：EP2056860A2
公开(公告)日：2009-05-13
申请号：EP07864668.4
申请日：2007-11-20
申请人： Genentech, Inc.
发明人： GURNEY, Austin L. , BALAZS, Mercedes , GHILARDI, Nico , HYMOWITZ, Sarah , HASS, Philip , STAROVASNIK, Melissa , WU, Yan , LEE, James M. , ARNOTT, David , OUYANG, Wenjun
CPC分类号： C07K16/244 , A61K38/2073 , A61K2039/505 , C07K14/54 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/40 , G01N2500/10 , G01N2800/24 , Y02A50/463
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17 A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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4.发明公开
公开(公告)号：EP1641822A2
公开(公告)日：2006-04-05
申请号：EP04754234.5
申请日：2004-06-02
申请人： GENENTECH, INC.
发明人： ARNOTT, David , GURNEY, Austin , HASS, Philip , LEE, James , WU, Yan
IPC分类号： C07K14/54 , C12N15/24 , C07K16/24 , C12N15/13 , A61K38/20 , A61K38/17 , A61K39/395 , G01N33/563 , G01N33/53 , C12P21/02
CPC分类号： C07K16/244 , A61K38/00 , C07K14/54 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/6869 , Y02A50/463 , Y02A50/473
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterolgous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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