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公开(公告)号：EP0848755A1
公开(公告)日：1998-06-24
申请号：EP96931450.0
申请日：1996-08-30
申请人： Genentech, Inc.
发明人： LEE, James , WOOD, William
IPC分类号： G01N33 , A61K31 , A61K38 , A61K48 , A61P9 , A61P17 , C07K14 , C07K16 , C07K19 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K16/22 , A61K38/00 , C07K14/52 , C07K14/71 , C07K2319/00 , C07K2319/30
摘要： A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.
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公开(公告)号：EP3594228A1
公开(公告)日：2020-01-15
申请号：EP19175735.0
申请日：2004-06-02
申请人： GENENTECH, INC.
发明人： WU, Yan , LEE, James , HASS, Phillip , GURNEY, Austin , ARNOTT, David
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterolgous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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公开(公告)号：EP3481963A1
公开(公告)日：2019-05-15
申请号：EP17743124.4
申请日：2017-07-10
发明人： KLIJN, Christiaan, Nicolaas , LEE, James , STOKOE, David, Hugh , GENTLEMAN, Robert , GNAD, Florian , GOLDSTEIN, Leonard, David , CHMIELECKI, Juliann , HARTMAIER, Ryan, J.
IPC分类号： C12Q1/68
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4.发明公开
公开(公告)号：EP1641822A2
公开(公告)日：2006-04-05
申请号：EP04754234.5
申请日：2004-06-02
申请人： GENENTECH, INC.
发明人： ARNOTT, David , GURNEY, Austin , HASS, Philip , LEE, James , WU, Yan
IPC分类号： C07K14/54 , C12N15/24 , C07K16/24 , C12N15/13 , A61K38/20 , A61K38/17 , A61K39/395 , G01N33/563 , G01N33/53 , C12P21/02
CPC分类号： C07K16/244 , A61K38/00 , C07K14/54 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/6869 , Y02A50/463 , Y02A50/473
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterolgous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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公开(公告)号：EP0577752A1
公开(公告)日：1994-01-12
申请号：EP92910478.0
申请日：1992-03-23
申请人： GENENTECH, INC.
IPC分类号： A61K39 , A61K38 , C07K1 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , C12Q1 , G01N33 , C12R1
CPC分类号： C07K16/2866 , A61K38/00 , A61K39/00 , C07K14/7155 , C07K2319/00
摘要： On a identifié dans des tissus humains des ADNc codant une classe de nouveaux PF4AR. Cette invention concerne des séquences d'acide nucléique de trois PF4AR (comprenant le récepteur humain IL-8) qui sont utiles pour le diagnostic et dans la préparation par recombinaison des PF4AR. On utilise les PF4AR pour préparer et purifier des anticorps pouvant se fixer sur des récepteurs, et pour effectuer des analyses diagnostiques.
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公开(公告)号：EP0848755B2
公开(公告)日：2011-02-09
申请号：EP96931450.9
申请日：1996-08-30
申请人： Genentech, Inc.
发明人： LEE, James , WOOD, William
CPC分类号： C07K16/22 , A61K38/00 , C07K14/52 , C07K14/71 , C07K2319/00 , C07K2319/30
摘要： A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.
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公开(公告)号：EP0577752B2
公开(公告)日：2007-07-11
申请号：EP92910478.4
申请日：1992-03-23
申请人： GENENTECH, INC.
IPC分类号： C12N15/12 , C12N15/10 , C07K14/705 , C12P21/08 , C12N5/10
CPC分类号： C07K16/2866 , A61K38/00 , A61K39/00 , C07K14/7155 , C07K2319/00
摘要： cDNAs encoding a class of novel PF4ARs has been identified in human tissue. Provided herein are nucleic acid sequences of three PF4ARs (including the human IL-8 receptor) useful as a diagnostic and in the recombinant preparation of PF4ARs. The PF4ARs are used in the preparation and purification of antibodies capable of binding to the receptors, and in diagnostic assays.
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公开(公告)号：EP0577752B1
公开(公告)日：2000-07-05
申请号：EP92910478.4
申请日：1992-03-23
申请人： GENENTECH, INC.
IPC分类号： C12N15/12 , C12N15/10 , C07K14/705 , C12P21/08 , C12N5/10
CPC分类号： C07K16/2866 , A61K38/00 , A61K39/00 , C07K14/7155 , C07K2319/00
摘要： cDNAs encoding a class of novel PF4ARs has been identified in human tissue. Provided herein are nucleic acid sequences of three PF4ARs (including the human IL-8 receptor) useful as a diagnostic and in the recombinant preparation of PF4ARs. The PF4ARs are used in the preparation and purification of antibodies capable of binding to the receptors, and in diagnostic assays.
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公开(公告)号：EP1641822B1
公开(公告)日：2013-05-15
申请号：EP04754234.5
申请日：2004-06-02
申请人： Genentech, Inc.
发明人： ARNOTT, David , GURNEY, Austin , HASS, Philip , LEE, James , WU, Yan
CPC分类号： C07K16/244 , A61K38/00 , C07K14/54 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/6869 , Y02A50/463 , Y02A50/473
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterolgous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及一种新型天然存在的人类细胞因子，其由本文称为白细胞介素17A / F（IL-17A / F）的白细胞介素-17和白细胞介素-17F的异源二聚体组成。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的特异性抗体以及与本发明的多肽结合的方法 本发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：EP0848755B9
公开(公告)日：2004-02-04
申请号：EP96931450.9
申请日：1996-08-30
申请人： Genentech, Inc.
发明人： LEE, James , WOOD, William
CPC分类号： C07K16/22 , A61K38/00 , C07K14/52 , C07K14/71 , C07K2319/00 , C07K2319/30
摘要： A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.
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