公开(公告)号：EP1326980A2

公开(公告)日：2003-07-16

申请号：EP01987803.2

申请日：2001-10-12

申请人： Genentech, Inc.

发明人： DESNOYER, Luc ,  FILVAROFF, Ellen, H. ,  PENNICA, Diane

IPC分类号： C12N15/12 ,  C07K14/47 ,  A61K38/17 ,  C12N15/62

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/47

摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.

公开(公告)号：EP1326980B1

公开(公告)日：2008-03-19

申请号：EP01987803.2

申请日：2001-10-12

申请人： GENENTECH, INC.

发明人： DESNOYER, Luc ,  FILVAROFF, Ellen, H. ,  PENNICA, Diane

IPC分类号： C12N15/12 ,  C07K14/47 ,  A61K38/17 ,  C12N15/62

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/47

公开(公告)号：EP1572931B1

公开(公告)日：2010-08-04

申请号：EP03739341.0

申请日：2003-06-28

申请人： Genentech, Inc.

发明人： DESNOYER, Luc ,  FILVAROFF, Ellen

IPC分类号： C07K16/28 ,  A61K39/395 ,  C12N15/12 ,  C12P21/08

CPC分类号： C07K16/22 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30

摘要： Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.

公开(公告)号：EP1572931A3

公开(公告)日：2005-09-28

申请号：EP03739341.0

申请日：2003-06-28

申请人： GENENTECH, INC.

发明人： DESNOYER, Luc ,  FILVAROFF, Ellen

IPC分类号： C07K16/28 ,  A61K39/395 ,  C12N15/12 ,  C12P21/08

公开(公告)号：EP1572931A2

公开(公告)日：2005-09-14

申请号：EP03739341.0

申请日：2003-06-28

申请人： GENENTECH, INC.

发明人： DESNOYER, Luc ,  FILVAROFF, Ellen

IPC分类号： C12N1/00

CPC分类号： C07K16/22 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30

摘要： Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.