公开(公告)号：EP1753463A2

公开(公告)日：2007-02-21

申请号：EP05804852.1

申请日：2005-05-31

申请人： GENENTECH, INC.

发明人： EBENS, JR., Allen J. ,  JACOBSON, Frederic S. ,  POLAKIS, Paul ,  SCHWALL, Ralph H. ,  SLIWKOWSKI, Mark X. ,  SPENCER, Susan D.

IPC分类号： A61K47/48 ,  A61P35/00 ,  G01N33/574

CPC分类号： A61K47/48569 ,  A61K47/6803 ,  A61K47/6875 ,  A61K2039/505 ,  C07D498/18 ,  C07K16/1063 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/283 ,  C07K16/2866 ,  C07K16/2896 ,  C07K16/3046 ,  C07K16/3069 ,  C07K16/32 ,  C07K2317/24

摘要： The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)p where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.

公开(公告)号：EP1696963A2

公开(公告)日：2006-09-06

申请号：EP04815573.3

申请日：2004-12-21

申请人： GENENTECH, INC.

发明人： CHANG, Wesley ,  DE SAUVAGE, Frederic ,  EATON, Dan L. ,  EBENS, JR., Allen J. ,  FRANTZ, Gretchen ,  HONGO, Jo-Anne S. ,  KOEPPEN, Hartmut ,  POLSON, Andrew ,  SMITH, Victoria

IPC分类号： A61K47/48

CPC分类号： C07K16/3061 ,  A61K47/6803 ,  A61K47/6867 ,  A61K2039/505 ,  C07K14/705

摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same