公开(公告)号：EP2258848B1

公开(公告)日：2014-03-05

申请号：EP10009491.1

申请日：2000-12-20

申请人： Genentech, Inc.

发明人： Chen, Jian ,  Filvaroff, Ellen ,  Fong, Sherman ,  Goddard, Audrey ,  Godowski, Paul J. ,  Grimaldi, Christopher J. ,  Gurney, Austin L. ,  Li, Hanzhong ,  Hillan, Kenneth J. ,  Tumas, Daniel ,  Van Lookeren, Menno ,  Vandlen, Richard L. ,  Watanabe, Colin K. ,  Williams, P., Mickey ,  Wood, William I. ,  Yansura, Daniel G.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C07K14/54 ,  C12N15/62 ,  C07K16/24 ,  C07K16/28 ,  A61K31/70 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  G01N33/566

CPC分类号： A61K38/20 ,  C07K14/54 ,  C07K14/7155 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/15

公开(公告)号：EP1897945B1

公开(公告)日：2012-01-18

申请号：EP07016901.6

申请日：2000-12-20

申请人： Genentech, Inc.

发明人： Chen, Jian ,  Filvaroff, Ellen ,  Fong, Sherman ,  Goddard, Audrey ,  Godowski, Paul J. ,  Grimaldi, Christopher J. ,  Gurney, Austin L. ,  Li, Hanzhong ,  Hillan, Kenneth J. ,  Tumas, Daniel ,  Van Lookeren, Menno ,  Vandlen, Richard L. ,  Watanabe, Colin K. ,  Williams, P. Mickey ,  Wood, William I. ,  Yansura, Daniel G.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C07K14/54 ,  C12N15/62 ,  C07K16/24 ,  C07K16/28 ,  A61K31/70 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  G01N33/566

CPC分类号： A61K38/20 ,  C07K14/54 ,  C07K14/7155 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/15

公开(公告)号：EP2290081A2

公开(公告)日：2011-03-02

申请号：EP10009490.3

申请日：2000-12-20

申请人： Genentech, Inc.

发明人： Chen, Jian ,  Filvaroff, Ellen ,  Fong, Sherman ,  Goddard, Audrey ,  Godowski, Paul J. ,  Grimaldi, Christopher J. ,  Gurney, Austin L. ,  Li, Hanzhong ,  Hillan, Kenneth J. ,  Tumas, Daniel ,  Van Lookeren, Menno ,  Vandlen, Richard L. ,  Watanabe, Colin K. ,  Williams, P., Mickey ,  Wood, William I. ,  Yansura, Daniel G.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C07K14/54 ,  C12N15/62 ,  C07K16/24 ,  C07K16/28 ,  A61K31/70 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  G01N33/566

CPC分类号： A61K38/20 ,  C07K14/54 ,  C07K14/7155 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/15

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein a re vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含这些核酸序列的重组载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明多肽结合的抗体以及产生本发明多肽的方法 本发明。

公开(公告)号：EP1944317A3

公开(公告)日：2008-09-17

申请号：EP07022176.7

申请日：2001-08-29

申请人： Genentech, Inc.

发明人： Baker, Kelvin P. ,  Eaton, Dan L. ,  Filvaroff, Ellen ,  Goddard, Audrey ,  Grimaldi, J. Christopher ,  Gurney, Austin L. ,  Smith, Victoria ,  Stephan, Jean-Philippe ,  Watanabe, Colin K. ,  Wood, William I. ,  Zhang, Zemin ,  Fong, Sherman

IPC分类号： C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N15/12 ,  C12N15/62 ,  A61K38/17

CPC分类号： C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：EP1944317A2

公开(公告)日：2008-07-16

申请号：EP07022176.7

申请日：2001-08-29

申请人： Genentech, Inc.

发明人： Baker, Kelvin P. ,  Eaton, Dan L. ,  Filvaroff, Ellen ,  Goddard, Audrey ,  Grimaldi, J. Christopher ,  Gurney, Austin L. ,  Smith, Victoria ,  Stephan, Jean-Philippe ,  Watanabe, Colin K. ,  Wood, William I. ,  Zhang, Zemin ,  Fong, Sherman

IPC分类号： C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N15/12 ,  C12N15/62 ,  A61K38/17

CPC分类号： C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：EP1897946A2

公开(公告)日：2008-03-12

申请号：EP07016902.4

申请日：2000-12-20

申请人： Genentech, Inc.

发明人： Chen, Jian ,  Filvaroff, Ellen ,  Fong, Sherman ,  Goddard, Audrey ,  Godowski, Paul J. ,  Grimaldi, Christopher J. ,  Gurney, Austin L. ,  Li, Hanzhong ,  Hillan, Kenneth J. ,  Tumas, Daniel ,  Van Lookeren, Menno ,  Vandlen, Richard L. ,  Watanabe, Colin K. ,  Williams, P. Mickey ,  Wood, William I. ,  Yansura, Daniel G.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C07K14/54 ,  C12N15/62 ,  C07K16/24 ,  C07K16/28 ,  A61K31/70 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  G01N33/566

CPC分类号： A61K38/20 ,  C07K14/54 ,  C07K14/7155 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/15

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein a re vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：EP1892249A1

公开(公告)日：2008-02-27

申请号：EP07019808.0

申请日：2000-08-24

申请人： Genentech, Inc.

发明人： Eaton, Dan L. ,  Filvaroff, Ellen ,  Gerritsen, Mary E. ,  Goddard, Audrey ,  Godowski, Paul J. ,  Grimaldi, Christopher J. ,  Gurney, Austin L. ,  Watanabe, Colin K. ,  Wood, William I.

IPC分类号： C07K14/47 ,  C07K14/705 ,  C12N15/62 ,  C07K16/28 ,  C07K16/18

CPC分类号： C07K14/47 ,  C07K14/705 ,  C12Q1/6876 ,  C12Q2600/158

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：EP1865061A2

公开(公告)日：2007-12-12

申请号：EP07012170.2

申请日：1999-05-14

申请人： Genentech, Inc.

发明人： Chen, Jian ,  Filvaroff, Ellen ,  Goddard, Audrey ,  Gurney, Austin L. ,  Li, Hanzhong ,  Wood, William

IPC分类号： C12N15/19 ,  C07K14/52 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  C12Q1/68 ,  C12N15/62 ,  C07K16/24 ,  A61K38/19 ,  C12Q1/00

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/54 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptides molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

摘要翻译： 本发明涉及与IL-17具有序列同一性的多肽和编码那些多肽的核酸分子。 本文还提供了包含这些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了用于治疗退行性软骨疾病的方法中的试剂和组合物。

公开(公告)号：EP1623991A2

公开(公告)日：2006-02-08

申请号：EP05019536.1

申请日：2000-08-24

申请人： GENENTECH, INC.

发明人： Eaton, Dan L. ,  Filvaroff, Ellen ,  Gerritsen, Mary E. ,  Goddard, Audrey ,  Godowski, Paul J. ,  Grimaldi, Christopher J. ,  Gurney, Austin L. ,  Watanabe, Colin K. ,  Wood, William I.

IPC分类号： C07K14/47 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/47 ,  C07K14/705 ,  C12Q1/6876 ,  C12Q2600/158

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：EP1897946B1

公开(公告)日：2012-07-11

申请号：EP07016902.4

申请日：2000-12-20

申请人： Genentech, Inc.

发明人： Chen, Jian ,  Filvaroff, Ellen ,  Fong, Sherman ,  Goddard, Audrey ,  Godowski, Paul J. ,  Grimaldi, Christopher J. ,  Gurney, Austin L. ,  Li, Hanzhong ,  Hillan, Kenneth J. ,  Tumas, Daniel ,  Van Lookeren, Menno ,  Vandlen, Richard L. ,  Watanabe, Colin K. ,  Williams, P. Mickey ,  Wood, William I. ,  Yansura, Daniel G.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C07K14/54 ,  C12N15/62 ,  C07K16/24 ,  C07K16/28 ,  A61K31/70 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  G01N33/566

CPC分类号： A61K38/20 ,  C07K14/54 ,  C07K14/7155 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/15