公开(公告)号：EP1366161B1

公开(公告)日：2007-10-03

申请号：EP01986152.5

申请日：2001-12-07

申请人： GENENTECH, INC.

发明人： FRENCH, Dorothy ,  GRIMALDI, J. Christopher ,  HILLAN, Kenneth, J ,  PISABARRO, Maria, Teresa ,  SCHMIDT, Kerstin, N. ,  SMITH, Victoria ,  TUMAS, Daniel ,  VANDLEN, Richard, L. ,  WATANABE, Colin, K. ,  WILLIAMS, P. Mickey ,  WOOD, William, I. ,  EATON, Dan L.

IPC分类号： C12N15/12 ,  C07K14/54 ,  G01N33/53 ,  A61K39/00 ,  C12N5/10

CPC分类号： G01N33/567 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/47 ,  C12N15/8509 ,  G01N33/57484 ,  G01N2800/52

摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.