-
1.发明授权NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR 失效非肽整合素具有特异性抑制剂用于糖蛋白IIb IIIa受体
公开(公告)号：EP0610334B1
公开(公告)日：1996-01-24
申请号：EP92922468.1
申请日：1992-10-15
申请人： GENENTECH, INC.
发明人： BLACKBURN, Brent , BARKER, Peter , GADEK, Thomas , McDOWELL, Robert , McGEE, Lawrence , SOMERS, Todd , WEBB, Rob , ROBARGE, Kirk
IPC分类号： C07D243/14 , A61K31/55 , C07D223/16 , C07D267/14
CPC分类号： C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14
摘要： A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIbIIIa receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
-
2.发明公开NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR 失效非肽整合素具有特异性的糖蛋白IIb IIIa受体抑制剂。
公开(公告)号：EP0610334A1
公开(公告)日：1994-08-17
申请号：EP92922468.0
申请日：1992-10-15
申请人： GENENTECH, INC.
发明人： BLACKBURN, Brent , BARKER, Peter , GADEK, Thomas , McDOWELL, Robert , McGEE, Lawrence , SOMERS, Todd , WEBB, Rob , ROBARGE, Kirk
CPC分类号： C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14
摘要： Un dérivé de benzodiazépinedione intervient en tant qu'inhibiteur non peptidyle d'aggrégation des plaquettes. Il inhibe fortement la liaison des fibrinogènes au récepteur GPIIbIIIa et figure dans des compositions thérapeutiques relatives au traitement de maladies pour lesquelles il convient de bloquer l'aggrégation des plaquettes. Ces inhibiteurs non peptidyles sont combinés avec des thrombolytiques et des anticoagulants.
-
搜索结果
2 条记录 (耗时 0.015 秒)
